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Titolo:
IMMUNOHISTOCHEMICAL PATHOLOGY OF THE CORNEAL ENDOTHELIUM IN IRIDOCORNEAL ENDOTHELIAL SYNDROME
Autore:
HIRST LW; BANCROFT J; YAMAUCHI K; RICHARD W; GREEN WR;
Indirizzi:
PRINCESS ALEXANDRA HOSP,DIV OPHTHALMOL,IPSWICH RD WOOLLOONGABBA QLD 4102 AUSTRALIA NAGAZUMI CHYOU GIFU JAPAN JOHNS HOPKINS UNIV HOSP,OCULAR PATHOL LAB BALTIMORE MD 00000
Titolo Testata:
Investigative ophthalmology & visual science
fascicolo: 5, volume: 36, anno: 1995,
pagine: 820 - 827
SICI:
0146-0404(1995)36:5<820:IPOTCE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESSENTIAL IRIS ATROPHY; COGAN-REESE SYNDROME; CHANDLERS SYNDROME; DISEASE; CELLS; PATHOGENESIS; CYTOKERATIN; EXPRESSION; DYSTROPHY; SPECTRUM;
Keywords:
IRIDOCORNEAL ENDOTHELIAL SYNDROME (ICE); KERATIN STAINING; INTERMEDIATE FILAMENTS; EPITHELIAL CHARACTERISTICS; TRANSMISSION ELECTRON MICROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
L.W. Hirst et al., "IMMUNOHISTOCHEMICAL PATHOLOGY OF THE CORNEAL ENDOTHELIUM IN IRIDOCORNEAL ENDOTHELIAL SYNDROME", Investigative ophthalmology & visual science, 36(5), 1995, pp. 820-827

Abstract

Purpose. To evaluate immunohistochemical staining of the endothelia of corneas from patients with clinical diagnoses of iridocorneal endothelial (ICE) syndrome. Methods. Corneas diagnosed with ICE syndrome andremoved during corneal transplantation were freshly frozen, sectioned, and stained with monoclonal antibodies to keratin subgroups, vimentin, desmin, and a series of other antibodies against intermediate filaments. Transmission electron microscopy was performed on segments of these corneas fixed in glutaraldehyde. Results. There was almost universal staining of the endothelial layer with A1 and A3 keratin monoclonalantibodies and vimentin. Transmission electron microscopy of the corneas also confirmed features consistent with keratin. Conclusions. The ''endothelial'' cell layer in the iridocorneal endothelial syndrome has electron microscopic and immunohistochemical characteristics of epithelial-like cells, but it also cross-reacts with vimentin, suggesting that these cells retain or derive some endothelial staining characteristics as well. This ''epithelialization'' of the endothelial layer mayexplain the progressive cellular proliferation across angle and iris similar to that seen in iatrogenic epithelial downgrowth and posteriorpolymorphous endothelial dystrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:38:41