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Titolo:
IN-VITRO STUDIES ON A NOVEL MICELLE-FORMING PEPTIDE WITH ANTICOAGULANT ACTIVITY
Autore:
RAMESH CV; JAYAKUMAR R; PUVANAKRISHNAN R;
Indirizzi:
CENT LEATHER RES INST,DEPT BIOTECHNOL MADRAS 600020 TAMIL NADU INDIA CENT LEATHER RES INST,DEPT BIOTECHNOL MADRAS 600020 TAMIL NADU INDIA CENT LEATHER RES INST,CHEM LAB MADRAS 600020 TAMIL NADU INDIA
Titolo Testata:
International journal of peptide & protein research
fascicolo: 4, volume: 45, anno: 1995,
pagine: 386 - 390
SICI:
0367-8377(1995)45:4<386:ISOANM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHETIC THROMBIN INHIBITORS; BLOOD-COAGULATION; INVITRO; MEMBRANES; INVIVO;
Keywords:
ANTICOAGULANT; MICELLE; PEPTIDE; THROMBIN INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
C.V. Ramesh et al., "IN-VITRO STUDIES ON A NOVEL MICELLE-FORMING PEPTIDE WITH ANTICOAGULANT ACTIVITY", International journal of peptide & protein research, 45(4), 1995, pp. 386-390

Abstract

A novel peptide, tert-butyloxycarbonyl-L-arginine-L-proline lauryl ester laurate, synthesised by a solution-phase method, formed micelles in aqueous solutions and was observed to exhibit anticoagulant activityas shown by clotting assays such as the thrombin time (TT) test, the prothrombin time (PT) test and the activated partial thromboplastin time (APTT) lest. TT and PT were found to be normal up to a particular concentration of peptide, and above that level they increased with increasing concentration of peptide, while APTT did not exhibit much significance. Conductometric and potentiometric studies showed that the peptide formed a stable micelle, and the anticoagulant activity of this peptide was also compared with a non-arginine-containing peptide (control) known to form micelles. The anticoagulant action in the micellar form could be due to the inhibition of thrombin, as seen from the decrease in amidolytic activity. The inhibitory activity of the peptide wasexplained in the light of micelle formation. (C) Munksgaard 1995.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:33:31