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Titolo:
HUMAN EOSINOPHIL GRANULE MAJOR BASIC-PROTEIN AND SYNTHETIC POLYCATIONS INDUCE AIRWAY HYPERRESPONSIVENESS IN-VIVO DEPENDENT ON BRADYKININ GENERATION
Autore:
COYLE AJ; ACKERMAN SJ; BURCH R; PROUD D; IRVIN CG;
Indirizzi:
CIBA GEIGY AG,DEPT ASTHMA & ALLERGY CH-4002 BASEL SWITZERLAND UNIV COLORADO,HLTH SCI CTR,DEPT MED,DIV PULM SCI DENVER CO 80206 NATL JEWISH CTR IMMUNOL & RESP MED DENVER CO 80206 BETH ISRAEL HOSP,DEPT MED,DIV INFECT DIS BOSTON MA 02215 HARVARD UNIV,SCH MED BOSTON MA 02115 ZENECA PHARMACEUT WILMINGTON DE 19897 JOHNS HOPKINS ASTHMA & ALLERGY CTR BALTIMORE MD 21224
Titolo Testata:
The Journal of clinical investigation
fascicolo: 4, volume: 95, anno: 1995,
pagine: 1735 - 1740
SICI:
0021-9738(1995)95:4<1735:HEGMBA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING FACTOR; INDUCED ALLERGIC RHINITIS; CATIONIC PROTEINS; GUINEA-PIG; TISSUE KALLIKREIN; INDUCED BRONCHOCONSTRICTION; BRONCHOALVEOLAR LAVAGE; MICROVASCULAR LEAKAGE; ASTHMATIC SUBJECTS; NASAL SECRETIONS;
Keywords:
CATIONIC PROTEIN; EOSINOPHIL; MAJOR BASIC PROTEIN; BRADYKININ; AIRWAY HYPERRESPONSIVENESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Coyle et al., "HUMAN EOSINOPHIL GRANULE MAJOR BASIC-PROTEIN AND SYNTHETIC POLYCATIONS INDUCE AIRWAY HYPERRESPONSIVENESS IN-VIVO DEPENDENT ON BRADYKININ GENERATION", The Journal of clinical investigation, 95(4), 1995, pp. 1735-1740

Abstract

In the current series of experiments we investigated the role of bradykinin in airway hyperresponsiveness induced by human eosinophil-granule major basic protein (MBP), Bronchoalveolar lavage was performed after intratracheal instillation of MBP or poly-L-lysine in anesthetized,intubated rats, and levels of immunoreactive kinins and kallikrein-like activity were determined, Both MBP and poly-L-lysine induced a three- and eightfold increase in levels of kallikrein-like activity and i-kinins, respectively, To determine whether kinin production is required for the development of airway hyperresponsiveness induced by cationic proteins, dose-response curves to methacholine were constructed before and 1 h after intratracheal instillation of either MBP or poly-L-lysine (100 mu g). MBP and poly-L-lysine induced an increase in airway responsiveness, which was inhibited by pretreatment with a selective BK-2 receptor antagonist, NPC 17713 (250 mu g/ml). Our results demonstrate that MBP and poly-L-lysine activate kallikrein and stimulate the generation of i-kinins in vivo, an effect that may be related to the cationic charge of these proteins, Furthermore, the ability of these proteins to increase airway responsiveness appears to be dependent on the generation of i-kinins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:00:19