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Titolo:
GLUTAMATE DECARBOXYLASE-ANTIBODIES, INSULIN-ANTIBODIES AND ISLET-CELL-ANTIBODIES AND HLA TYPING TO DETECT DIABETES IN A GENERAL POPULATION-BASED STUDY OF SWEDISH CHILDREN
Autore:
HAGOPIAN WA; SANJEEVI CB; KOCKUM I; LANDINOLSSON M; KARLSEN AE; SUNDKVIST G; DAHLQUIST G; PALMER J; LERNMARK A;
Indirizzi:
UNIV WASHINGTON,DEPT MED,RG-20 SEATTLE WA 98195 KAROLINSKA INST,DEPT MOLEC MED S-17176 STOCKHOLM SWEDEN UNIV LUND HOSP,DEPT MED S-22185 LUND SWEDEN STENO DIABET CTR DK-2820 GENTOFTE DENMARK LUND UNIV,MALMO GEN HOSP,DEPT MED S-21461 MALMO SWEDEN UMEA UNIV,DEPT PEDIAT S-90185 UMEA SWEDEN
Titolo Testata:
The Journal of clinical investigation
fascicolo: 4, volume: 95, anno: 1995,
pagine: 1505 - 1511
SICI:
0021-9738(1995)95:4<1505:GDIAI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID DECARBOXYLASE; AUTOANTIBODIES; MELLITUS; AUTOANTIGEN; ONSET; ASSAY; RISK; RELATIVES; REGISTER; PRECEDE;
Keywords:
AUTOIMMUNITY; PREDICTION; IAA; GAD; INSULIN-DEPENDENT DIABETES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
W.A. Hagopian et al., "GLUTAMATE DECARBOXYLASE-ANTIBODIES, INSULIN-ANTIBODIES AND ISLET-CELL-ANTIBODIES AND HLA TYPING TO DETECT DIABETES IN A GENERAL POPULATION-BASED STUDY OF SWEDISH CHILDREN", The Journal of clinical investigation, 95(4), 1995, pp. 1505-1511

Abstract

Most autoimmune diabetes occurs in those without a diabetic relative,but few cases are identifiable prospectively, To model general population prediction, 491 consecutive newly diabetic children from all of Sweden were tested for autoantibodies to glutamate decarboxylase (GAD65ab), insulin (IAA), and islet cells (ICA), and for HLA-DQ genotypes byPCR; 415 matched control children were tested in parallel. GAD65ab sensitivity/specificity was 70/96%, versus 84/96% for ICA, 56/97% for IAA, 93/93% (any positive), 39/99.7% (all positive), and 41/99.7% (GAD65ab plus IAA), The latter's 25% predictive value was not improved by requiring concomitant high-risk HLA genotypes, GAD65ab were associated with DQA10501/B1*0201 (DQ2; P = 0.007) but not DQA1*0301/B1*0302 (DQ8), and IAA with DQA10301/B1*0302 (DQ8; P = 0.03);but not DQA1*0501/B1*0201 (DQ2), GAD65ab were more prevalent in females than males (79 vs, 63%; P < 0.0001) but did not vary with onset age nor season, Combiningthe three antibody assays yielded sufficient sensitivity for screening, GADab were relatively sensitive/specific for diabetes, but even with HLA marker combinations yielded predictive values insufficient for early immunointervention in the low-prevalence general population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:53:16