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Titolo:
ANTIOXIDANT LAZAROIDS ENHANCE DIFFERENTIATION OF C2 SKELETAL-MUSCLE CELLS
Autore:
VERNIER A; METZINGER L; WARTER JM; POINDRON P; PASSAQUIN AC;
Indirizzi:
UNIV LOUIS PASTEUR STRASBOURG 1,DEPT IMMUNOL IMMUNOPHARMACOL & PATHOL,BP24 F-67401 ILLKIRCH GRAFFENS FRANCE UNIV LOUIS PASTEUR STRASBOURG 1,DEPT IMMUNOL IMMUNOPHARMACOL & PATHOLF-67401 ILLKIRCH GRAFFENS FRANCE CLIN NEUROL 2 ILLKIRCH GRAFFENS FRANCE
Titolo Testata:
Neuroscience letters
fascicolo: 2-3, volume: 186, anno: 1995,
pagine: 177 - 180
SICI:
0304-3940(1995)186:2-3<177:ALEDOC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUCHENNE MUSCULAR-DYSTROPHY; ACETYLCHOLINE-RECEPTOR EXPRESSION; MYOGENESIS; MOUSE; CULTURES; THERAPY; PREDNISOLONE; DISEASES; PROTEIN; DAMAGE;
Keywords:
PREDNISOLONE; MUSCLE REGENERATION; DUCHENNE MUSCULAR DYSTROPHY; LAZAROIDS; U-74006F; C2 SKELETAL MUSCLE CULTURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Vernier et al., "ANTIOXIDANT LAZAROIDS ENHANCE DIFFERENTIATION OF C2 SKELETAL-MUSCLE CELLS", Neuroscience letters, 186(2-3), 1995, pp. 177-180

Abstract

We have examined the incidence of new antioxidant compounds, so-called lazaroids, on the morphological and biochemical aspects of differentiation of C2 mouse skeletal muscle cells. We show that three lazaroids(U-74006F U-74389F and U-83836E) enhance fusion of myogenic cells when added at the day of fusion. A parallel increase in nicotinic acetylcholine receptor expression and skeletal muscle a-actin content was observed. This promoting effect of lazaroids on myogenesis could be related to inhibition of free radical-mediated muscle damage. Therefore, one could expect that lazaroids might he useful in the treatment of degenerating muscle diseases such as Duchenne muscular dystrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 21:29:53