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Titolo:
ANXIOLYTIC EFFECT OF THE 5-HT1A COMPOUNDS 8-HYDROXY-2-(DI-N-PROPYLAMINO) TETRALIN AND IPSAPIRONE IN THE SOCIAL-INTERACTION PARADIGM - EVIDENCE OF A PRESYNAPTIC ACTION
Autore:
PICAZO O; LOPEZRUBALCAVA C; FERNANDEZGUASTI A;
Indirizzi:
CINVESTAV IPN,DEPT PHARMACOL,POB 22026 MEXICO CITY 14000 DF MEXICO CINVESTAV IPN,DEPT FARMACOL TOXICOL,SECC TERAPEUT EXPTL MEXICO CITY DF MEXICO INST MEXICANO PSIQUIATRIA,DIV INVEST NEUROCIENCIAS MEXICO CITY DF MEXICO
Titolo Testata:
Brain research bulletin
fascicolo: 2, volume: 37, anno: 1995,
pagine: 169 - 175
SICI:
0361-9230(1995)37:2<169:AEOT5C>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; RECEPTOR AGONISTS; DORSAL RAPHE; PARA-CHLOROPHENYLALANINE; ANIMAL-MODELS; SEROTONERGIC ANXIOLYTICS; SELECTIVE AGONISTS; MEDIAN RAPHE; ANXIETY; 8-OH-DPAT;
Keywords:
8-OH-DPAT; IPSAPIRONE; SOCIAL INTERACTION TEST; PRESYNAPTIC ACTIVITY; INTRARAPHE; INTRAHIPPOCAMPAL; 5,7-DHT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
O. Picazo et al., "ANXIOLYTIC EFFECT OF THE 5-HT1A COMPOUNDS 8-HYDROXY-2-(DI-N-PROPYLAMINO) TETRALIN AND IPSAPIRONE IN THE SOCIAL-INTERACTION PARADIGM - EVIDENCE OF A PRESYNAPTIC ACTION", Brain research bulletin, 37(2), 1995, pp. 169-175

Abstract

This study analyses at which site, pre- or postsynaptic, the 5-HT(1)Aligands-8-hydroxy-2-(di-n-propylamina) tetralin (8-OH-DPAT) and ipsapirone-induce their anxiolytic action, The experimental anxiety was assessed in the social interaction test An anxiolytic action was observedafter the systemic administration of 8-OH-DPAT (0.25 and 0.5 mg/kg) and ipsapirone (5 but not 10 mg/ kg), In 5,7-dihydroxybyptamine (5,7-DHT, 150 mu g/10 mu l) lesioned rats Be anxiolytic effect of 8-OH-DPAT and ipsapirone was not observed, suggesting a presynaptic action of these drugs. When directly injected into the dorsal raphe nucleus 8-OH-DPAT (0.1 mu g/mu l) and ipsapirone (0.2 mu g/mu l) both compounds produce anxiolytic effects, At same doses, these drugs lacked an effect after their intrahippocampal infusion, All data strongly suggest that both drugs act presynaptically to reduce the anxiety levels in the socialinteraction paradigm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:00:09