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Titolo:
GLYCOGEN-SYNTHASE KINASE-3 AND DORSOVENTRAL PATTERNING IN XENOPUS EMBRYOS
Autore:
HE X; SAINTJEANNET JP; WOODGETT JR; VARMUS HE; DAWID IB;
Indirizzi:
NCI,VARMUS LAB,BLDG 49,ROOM 4A56 BETHESDA MD 20892 NICHHD,GENET MOLEC LAB BETHESDA MD 20892 ONTARIO CANC INST TORONTO ON M4X 1K9 CANADA
Titolo Testata:
Nature
fascicolo: 6523, volume: 374, anno: 1995,
pagine: 617 - 622
SICI:
0028-0836(1995)374:6523<617:GKADPI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEIN-4; MESODERM INDUCTION; SPEMANN ORGANIZER; VENTRALIZING FACTOR; AXIAL MESODERM; BODY AXIS; EXPRESSION; DROSOPHILA; WINGLESS; XWNT-8;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
X. He et al., "GLYCOGEN-SYNTHASE KINASE-3 AND DORSOVENTRAL PATTERNING IN XENOPUS EMBRYOS", Nature, 374(6523), 1995, pp. 617-622

Abstract

Glycogen synthase kinase 3 (GSK-3) is homologous to the product of the Drosophila gene shaggy (zeste-white 3), which is required for signalling by wingless during Drosophila development. To test whether GSK-3 is also involved in vertebrate pattern formation, its role was investigated during early Xenopus development. It was found that dominant-negative GSK-3 mutants induced dorsal differentiation, whereas wild-type GSK-3 induced ventralization. These results indicate that GSK-3 is required for ventral differentiation, and suggest that dorsal differentiation may involve the suppression of GSK-3 activity by a wingless/wnt-related signal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:23:08