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Titolo:
ELECTROPHYSIOLOGICAL CHARACTERIZATION OF THE INHIBITORY EFFECT OF A NOVEL PEPTIDE GURMARIN ON THE SWEET TASTE RESPONSE IN RATS
Autore:
MIYASAKA A; IMOTO T;
Indirizzi:
TOTTORI UNIV,FAC MED,DEPT PHYSIOL,86 NISHIMACHI YONAGO TOTTORI 683 JAPAN TOTTORI UNIV,FAC MED,DEPT PHYSIOL YONAGO TOTTORI 683 JAPAN
Titolo Testata:
Brain research
fascicolo: 1, volume: 676, anno: 1995,
pagine: 63 - 68
SICI:
0006-8993(1995)676:1<63:ECOTIE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACIDS; GYMNEMA-SYLVESTRE; NERVE RESPONSES; ZIZIPHUS-JUJUBA; CHORDA TYMPANI; LEAVES; STIMULI; PURIFICATION;
Keywords:
GURMARIN; ANTI-SWEET TASTE; RAT; GYMNEMA SYLVESTRE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A. Miyasaka e T. Imoto, "ELECTROPHYSIOLOGICAL CHARACTERIZATION OF THE INHIBITORY EFFECT OF A NOVEL PEPTIDE GURMARIN ON THE SWEET TASTE RESPONSE IN RATS", Brain research, 676(1), 1995, pp. 63-68

Abstract

The effect of an anti-sweet peptide, gurmarin purified from the leaves of Gymnema sylvestre, was studied electrophysiologically on taste responses of the rat chorda tympani. The action of gurmarin was highly specific to sweet taste so that responses to various sweeteners including sugars, sweet amino acids and an artificial sweetener, saccharin were all suppressed. The most effective pH at which the rat tongue was treated with gurmarin was found to be 4.5, which corresponds to the isoelectric point of the peptide. At this condition about 5 mu M of gurmarin was sufficient to reveal maximal effect and this was still significant at 0.5 mu M (2 mu g/ml). Although the suppressed responses required several hours to attain complete recovery, anti-gurmarin serum shortened the recovery time considerably. On the other hand, intravenous injection of gurmarin did not cause any significant effects on taste responses at all. These results suggest that gurmarin acts on the apicalside of the taste cell, possibly by binding to the sweet taste receptor protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 21:47:14