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Titolo:
ESTRADIOL INDUCES BOTH QUALITATIVE AND QUANTITATIVE CHANGES IN THE PATTERN OF GONADOTROPIN-RELEASING-HORMONE SECRETION DURING THE PRESURGE PERIOD IN THE EWE
Autore:
EVANS NP; DAHL GE; MAUGER D; KARSCH FJ;
Indirizzi:
UNIV MICHIGAN,REPROD SCI PROGRAM,300 N INGALLS BLDG,ROOM 1101 SW ANN ARBOR MI 48109 UNIV MICHIGAN,REPROD SCI PROGRAM ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT PHYSIOL & BIOPHYS ANN ARBOR MI 48109
Titolo Testata:
Endocrinology
fascicolo: 4, volume: 136, anno: 1995,
pagine: 1603 - 1609
SICI:
0013-7227(1995)136:4<1603:EIBQAQ>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA LUTEINIZING-HORMONE; OVARIECTOMIZED EWES; GNRH SECRETION; ESTROUS-CYCLE; PITUITARY RESPONSIVENESS; RHESUS-MONKEY; LH-RH; FREQUENCY; PULSES; AMPLITUDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
N.P. Evans et al., "ESTRADIOL INDUCES BOTH QUALITATIVE AND QUANTITATIVE CHANGES IN THE PATTERN OF GONADOTROPIN-RELEASING-HORMONE SECRETION DURING THE PRESURGE PERIOD IN THE EWE", Endocrinology, 136(4), 1995, pp. 1603-1609

Abstract

The follicular phase rise in circulating estradiol causes a suppression of GnRH pulse amplitude and an increase in pulse frequency before stimulation of the preovulatory GnRH surge in the ewe. Studies in whichsamples were collected at 10-min intervals were found unsuitable to determine whether GnRH secretion is exclusively pulsatile at this time or whether estradiol induces additional qualitative changes in the pattern of GnRH secretion that, combined with the quantitative changes, result in generation of the surge. To address these issues, GnRH was measured in pituitary portal blood and LH in peripheral blood collected at 1- and 10-min intervals, respectively, in ewes receiving no estradiol (n = 5), a luteal phase level of circulating estradiol (n = 5), or a peak follicular phase concentration of estradiol (n = 5). The results provide evidence that, in a dose-dependent manner, estradiol inducesthe secretion of significant amounts of GnRH between pulses and alters the shape of GnRH pulses by reducing the slope of the rising and falling phases of each pulse. These findings lead to the conclusion that during the presurge period in the ewe, estradiol induces qualitative change in the pattern of GnRH release in addition to stimulating GnRH pulse frequency and reducing pulse amplitude.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:13:27