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Titolo:
IDENTIFICATION OF SPINAL INTERNEURONS ANTECEDENT TO ADRENAL SYMPATHETIC PREGANGLIONIC NEURONS USING TRANSSYNAPTIC TRANSPORT OF HERPES-SIMPLEX VIRUS TYPE-1
Autore:
JOSHI S; LEVATTE MA; DEKABAN GA; WEAVER LC;
Indirizzi:
UNIV WESTERN ONTARIO,JOHN P ROBARTS RES INST LONDON ON N6A 5K8 CANADA UNIV WESTERN ONTARIO,JOHN P ROBARTS RES INST LONDON ON N6A 5K8 CANADA UNIV WESTERN ONTARIO,DEPT PHYSIOL LONDON ON N6A 5K8 CANADA UNIV WESTERN ONTARIO,DEPT MICROBIOL & IMMUNOL LONDON ON N6A 5K8 CANADA
Titolo Testata:
Neuroscience
fascicolo: 3, volume: 65, anno: 1995,
pagine: 893 - 903
SICI:
0306-4522(1995)65:3<893:IOSIAT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSEUDORABIES VIRUS; TRANSNEURONAL TRANSPORT; SENSORY NEURONS; NERVOUS-SYSTEM; SUBSTANCE-P; RAT; RETROGRADE; INPUT; CAT; IMMUNOREACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S. Joshi et al., "IDENTIFICATION OF SPINAL INTERNEURONS ANTECEDENT TO ADRENAL SYMPATHETIC PREGANGLIONIC NEURONS USING TRANSSYNAPTIC TRANSPORT OF HERPES-SIMPLEX VIRUS TYPE-1", Neuroscience, 65(3), 1995, pp. 893-903

Abstract

Control of sympathetic preganglionic neurons appears to be mediated, in part, through polysynaptic pathways using spinal interneurons. To identify spinal interneurons antecedent to adrenal sympathetic preganglionic neurons, we injected herpes simplex virus type 1 into the adrenal gland of hamsters as this virus is an effective trans-synaptic tracer of neural pathways. After a three day survival period, immunocytochemistry was used to visualize virus-infected spinal cord cells. Infected sympathetic preganglionic neurons with somata that were either kite-shaped, elliptical or fusiform and that had extensive dendrite arbors were identified as well as a group of smaller round cells with finer processes. For comparison, in additional hamsters, labelling with the retrograde tracer Fluoro-Gold and histochemical reactions for the enzyme nicotinamide adenine dinucleotide phosphate-diaphorase were used to identify sympathetic preganglionic neurons. Sympathetic preganglionic neurons identified with Fluoro-Gold or herpes virus were present mostly in the nucleus intermediolateralis, pars intermediolateralis and nucleus intermediolateralis, pars funicularis of the spinal cord. The smaller herpes virus-infected cells were found mostly medial to the preganglionic neurons in lamina VII and also dorsally in lamina V of the spinal cord. Assessing immunoreactivity for glial fibrillary acidic protein demonstrated that the smaller herpes virus-infected cells were notreactive astrocytes. Furthermore, these cells were immunoreactive fortwo neuronal markers, neuron-specific enolase and for microtubule-associated protein 2. These findings suggest that these smaller round cells with finer processes are distinct from sympathetic preganglionic neurons and astrocytes and may be interneurons antecedent to the sympathetic preganglionic neurons.

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Documento generato il 30/11/20 alle ore 00:48:58