Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF THE CHOLECYSTOKININ RECEPTOR ANTAGONIST LOXIGLUMIDE ON PANCREATIC EXOCRINE FUNCTION IN RATS AFTER ACUTE-PANCREATITIS
Autore:
NAKANO S; TACHIBANA I; OTSUKI M;
Indirizzi:
UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT INTERNAL MED 3,YAHATANISHI KU,1-1 ISEIGAOKA KITAKYUSHU FUKUOKA 807 JAPAN UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT INTERNAL MED 3,YAHATANISHI KU KITAKYUSHU FUKUOKA 807 JAPAN
Titolo Testata:
Pancreas
fascicolo: 3, volume: 10, anno: 1995,
pagine: 287 - 294
SICI:
0885-3177(1995)10:3<287:EOTCRA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS CHOLECYSTOKININ; CERULEIN; REGENERATION; GROWTH; INVOLVEMENT; L-364,718; SECRETION; ACINI;
Keywords:
ACUTE PANCREATITIS; EXOCRINE PANCREAS; LOXIGLUMIDE; CHOLECYSTOKININ RECEPTOR ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
S. Nakano et al., "EFFECT OF THE CHOLECYSTOKININ RECEPTOR ANTAGONIST LOXIGLUMIDE ON PANCREATIC EXOCRINE FUNCTION IN RATS AFTER ACUTE-PANCREATITIS", Pancreas, 10(3), 1995, pp. 287-294

Abstract

Recent studies have demonstrated that cholecystokinin (CCK) receptor antagonists not only reduce the severity of pancreatitis but also inhibit pancreatic regeneration after pancreatitis. This study was undertaken, therefore, to examine the effects of the CCK receptor antagonist loxiglumide on the exocrine pancreas when given after an episode of acute pancreatitis that was induced in rats by a 4-h subcutaneous infusion of 20 mu g/kg body weight/h cerulein. Biochemical changes and secretory function in response to 100 ng/kg body weight cerulein were determined after a 6-day treatment with saline, loxiglumide (50 mg/kg body weight), or CCK-8 (2.5 mu g/kg body weight), which was given three times a day starting 24 h after the induction of acute pancreatitis. In the saline-treated rats, pancreatic enzyme contents and pancreatic juice and protein output were significantly low, whereas the pancreatic weight and protein and DNA contents were comparable to those of the controls without pancreatitis. Loxiglumide treatment, although significantly decreasing protein output, had no influence on pancreatic weight, protein and DNA contents, or pancreatic juice flow but increased the amylase and lipase contents compared to those of the saline-treated postpancreatitic rats. CCK-8 treatment also had no influence on pancreaticweight or protein and DNA contents but significantly increased the pancreatic enzyme contents and pancreatic juice and protein output compared to those of the saline-treated postpancreatitic rats. These results suggest that loxiglumide does not significantly inhibit the recoveryof exocrine pancreatic function but appears to accelerate the increase in pancreatic amylase and lipase contents even when given after an attack of acute pancreatitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:25:45