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Titolo:
THE ROLE OF CCK AND ITS ANALOGS IN THE ORGANOGENESIS OF THE FETAL-RATPANCREAS
Autore:
FEURLE GE; HAMSCHER G; FIRAT AE;
Indirizzi:
UNIV BONN,DRK KRANKENHAUS NEUWIED,MARKTSTR 74 D-56564 NEUWIED GERMANY
Titolo Testata:
Pancreas
fascicolo: 3, volume: 10, anno: 1995,
pagine: 281 - 286
SICI:
0885-3177(1995)10:3<281:TROCAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST; EMBRYONIC-DEVELOPMENT; CHOLECYSTOKININ; GROWTH; GASTRIN; L-364,718; RESPONSIVENESS; DIVERSION; CERULEIN; CELLS;
Keywords:
CHOLECYSTOKININ; GASTRIN; GASTROINTESTINAL HORMONES; PANCREATIC GROWTH; CHOLECYSTOKININ RECEPTOR ANTAGONIST; IMMUNE NEUTRALIZATION; FETAL DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
G.E. Feurle et al., "THE ROLE OF CCK AND ITS ANALOGS IN THE ORGANOGENESIS OF THE FETAL-RATPANCREAS", Pancreas, 10(3), 1995, pp. 281-286

Abstract

The gastrointestinal peptide cholecystokinin (CCK) has been shown to stimulate pancreatic growth in the adolescent and adult rat. However, little is known about the role of gastrointestinal hormones in the regulation of organ formation during fetal development. We therefore examined the effects of the CCK receptor antagonist devazepide (25 mu g/h)and an antigastrin/CCK monoclonal immunoglobulin G on the maternal and fetal rat pancreas. These substances were infused subcutaneously with minipumps in female rats during the entire period of gestation. At the end of gestation, the rats were killed and the pancreata of the dams and their litter were examined for DNA and protein. In the dams, thereceptor antagonist and the antibody against CCK/gastrin had no effect. In the newborns, the CCK receptor antagonist led to a significant reduction of the protein and DNA concentration [protein in controls, 105.0 +/- 3.75 mu g/mg pancreatic tissue; in the antagonist group, 91.9 /- 4.2 mu g/mg pancreatic tissue (p < 0.05); DNA in controls, 1.28 +/- 0.19 mu g/mg pancreatic tissue; in the antagonist group, 0.48 +/- 0.06 mu g/mg pancreatic tissue (p < 0.05) (mean +/- SEM)]. Immune neutralization of CCK/gastrin in the maternal-fetal circulation induced a reduction of the protein concentration in the fetal pancreas (85.3 +/- 3.06 mu g/mg pancreatic tissue; p < 0.01) but had no effect on fetal pancreatic DNA. Additional experiments indicated effective concentrations of the CCK receptor antagonist in fetal pancreatic tissue and free binding sites of the circulating antibody. In conclusion, the study provides evidence that CCK and its analogues are involved in fetal pancreatic organogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:37:33