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Titolo:
IL-12 EXACERBATES RATHER THAN SUPPRESSES T-HELPER 2-DEPENDENT PATHOLOGY IN THE ABSENCE OF ENDOGENOUS IFN-GAMMA
Autore:
WYNN TA; JANKOVIC D; HIENY S; ZIONCHECK K; JARDIEU P; CHEEVER AW; SHER A;
Indirizzi:
NIAID,IMMUNOL & CELL BIOL SECT,9000 ROCKVILLE PIKE,BLDG 4,ROOM 126 BETHESDA MD 20892 NIAID,PARASIT DIS LAB,HOST PARASITE RELAT SECT BETHESDA MD 20892 GENENTECH INC,DEPT IMMUNOL S SAN FRANCISCO CA 94080
Titolo Testata:
The Journal of immunology
fascicolo: 8, volume: 154, anno: 1995,
pagine: 3999 - 4009
SICI:
0022-1767(1995)154:8<3999:IERTST>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL STIMULATORY FACTOR; MURINE SCHISTOSOMIASIS-MANSONI; LYMPHOCYTE MATURATION FACTOR; INVIVO MOLECULAR ANALYSIS; GRANULOMA-FORMATION; IMMUNE-RESPONSE; MESSENGER-RNA; INFECTED MICE; FACTOR INTERLEUKIN-12; CYTOKINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Wynn et al., "IL-12 EXACERBATES RATHER THAN SUPPRESSES T-HELPER 2-DEPENDENT PATHOLOGY IN THE ABSENCE OF ENDOGENOUS IFN-GAMMA", The Journal of immunology, 154(8), 1995, pp. 3999-4009

Abstract

To assess the role of IFN-gamma in the in vivo regulation of Th subset? diferentiation by; IL-12, schistosome egg-induced Th2 responses andgranuloma formation were studied in IFN-gamma knock-out (gamma KO) mice in which the absence of endogenous IFN-gamma is assured. Rather than suppressing pathology and eosinophilia as observed in wild-type animals, exogenous IL-12 in egg-injected gamma KO mice exacerbated Th2-dependent granuloma formation while failing to reduce peak tissue eosinophilia. Similarly, instead of inhibiting its production, IL-12 caused adramatic increase in serum IgE levels in gamma KO animals after egg injection. Although the suppressive effects of IL-12 on Th2 responses were blocked in the absence of IFN-gamma, lymphocyte proliferation and IL-2 production were enhanced, a phenomenon which may underlie the observed exacerbation of egg-induced pathology. These findings formally establish that IL-12 inhibits Th2 development indirectly in vivo through the stimulation of IFN-gamma synthesis. In contrast, its promotion of Th1-associated responses seems to be at least partly a result of thedirect action of the cytokine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 01:01:42