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Titolo:
OPENING OF BRAIN POTASSIUM-CHANNELS INHIBITS THE ACTH-INDUCED BEHAVIORAL SYNDROME IN THE MALE-RAT
Autore:
VERGONI AV; SANDRINI M; FILAFERRO M; BERTOLINI A;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,VIA G CAMPI 287 I-41100 MODENA ITALY
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 188, anno: 1995,
pagine: 29 - 32
SICI:
0304-3940(1995)188:1<29:OOBPIT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE STIMULATING HORMONE; BETA-ENDORPHIN; MORPHINE ANALGESIA; MU-RECEPTOR; CYCLIC-AMP; PEPTIDES; MSH; CORTICOTROPIN; ACTH-(1-24); MODULATION;
Keywords:
K+ CHANNELS; PINACIDIL; MELANOCORTINS; BEHAVIOR; GROOMING; STRETCHING; YAWNING; PENILE ERECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
A.V. Vergoni et al., "OPENING OF BRAIN POTASSIUM-CHANNELS INHIBITS THE ACTH-INDUCED BEHAVIORAL SYNDROME IN THE MALE-RAT", Neuroscience letters, 188(1), 1995, pp. 29-32

Abstract

In adult male rats, the intracerebroventricular (i.c.v.) injection ofpinacidil, a potassium channel opener, at the doses of 100, 200 or 300 mu g/rat, dose-dependently reduced the display of the most typical behavioral symptoms (excessive grooming, stretching, yawning, penile erections) induced by the i.c.v. administration of ACTH-(1-24) (4 mu g/rat). These data indicate that the complex mechanism of the melanocortin-induced behavioral syndrome involves closure of potassium channels in target neurons, and provide further experimental support to the ideathat melanocortins are functional antagonists of opioids.

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Documento generato il 01/10/20 alle ore 07:17:21