Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
BRAIN CORTICOTROPIN-RELEASING FACTOR MEDIATES ANXIETY-LIKE BEHAVIOR INDUCED BY COCAINE WITHDRAWAL IN RATS
Autore:
SARNYAI Z; BIRO E; GARDI J; VECSERNYES M; JULESZ J; TELEGDY G;
Indirizzi:
HARVARD UNIV,MCLEAN HOSP,SCH MED,ALCOHOL & DRUG ABUSE RES CTR,115 MILL ST BELMONT MA 02178 ALBERT SZENT GYORGYI MED UNIV,DEPT PATHOPHYSIOL SZEGED HUNGARY ALBERT SZENT GYORGYI MED UNIV,DEPT MED 1,ENDOCRINE UNIT SZEGED HUNGARY
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 675, anno: 1995,
pagine: 89 - 97
SICI:
0006-8993(1995)675:1-2<89:BCFMAB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-LIKE IMMUNOREACTIVITY; ACOUSTIC STARTLE REFLEX; FACTOR CRF; INTERMITTENT COCAINE; CENTRAL NUCLEUS; HORMONE; STRESS; RESPONSES; ANTAGONIST; DEPRESSION;
Keywords:
COCAINE WITHDRAWAL; CORTICOTROPIN-RELEASING FACTOR; ANXIETY; PLUS MAZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
Z. Sarnyai et al., "BRAIN CORTICOTROPIN-RELEASING FACTOR MEDIATES ANXIETY-LIKE BEHAVIOR INDUCED BY COCAINE WITHDRAWAL IN RATS", Brain research, 675(1-2), 1995, pp. 89-97

Abstract

Anxiety is a key symptom of the cocaine withdrawal syndrome in human addicts, and it is considered to be one of the major factors in precipitating relapse to chronic cocaine abuse. Corticotropin-releasing factor (CRF) plays an important role in the pathophysiology of anxiety anddepression, and it may also be involved in the acute behavioral and neuroendocrine actions of cocaine. The role of endogenous CRF in cocaine withdrawal-induced anxiety was investigated in the present study. Animals were subjected to chronic cocaine (20 mg/kg, intraperitoneally, once a day for 14 days) administration. Rats tested 30 min after the last cocaine injection did not show withdrawal anxiety on the elevated plus maze or any alterations in brain CRF levels. Withdrawal (48 h) from chronic cocaine administration produced an intense anxiety-like behavior characterized by decreased open arm exploration. Immunoreactive CRF (CRF-LI) levels were selectively altered in the hypothalamus, in the amygdala and in the basal forebrain structures at the time of the behavioral anxiety, reflecting an increased activity of brain CRF systems. Daily intracerebroventricular (i.c.v.) pretreatment with an immunoserum raised against CRF completely prevented the development of anxiety induced by cocaine withdrawal. These data suggest that extrahypothalamic-limbic CRF hypersecretion may be involved in the development of anxiety related to cocaine withdrawal and that the CRF system may be auseful target for new pharmacotherapies for cocaine withdrawal and relapse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:15:11