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Titolo:
DIAPHRAGM THICKNESS HETEROGENEITY AT FUNCTIONAL RESIDUAL CAPACITY ANDTOTAL LUNG CAPACITY
Autore:
WAIT JL; STAWORN D; POOLE DC;
Indirizzi:
VET AFFAIRS MED CTR,DEPT INTERNAL MED,111F,4500 S LANCASTER RD DALLASTX 75216 VET AFFAIRS MED CTR,DEPT PEDIAT DALLAS TX 75216 UNIV TEXAS,SW MED SCH DALLAS TX 75216 UNIV CALIF SAN DIEGO,DEPT MED LA JOLLA CA 92093
Titolo Testata:
Journal of applied physiology
fascicolo: 3, volume: 78, anno: 1995,
pagine: 1030 - 1036
SICI:
8750-7587(1995)78:3<1030:DTHAFR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFERENT SARCOMERE LENGTHS; CANINE DIAPHRAGM; BLOOD-FLOW; INTRAMUSCULAR PRESSURE; SKELETAL-MUSCLE; BODY POSITION; INSITU; VOLUME; INVIVO; DOGS;
Keywords:
DIAPHRAGM CONFIGURATION; WALL STRESS; COSTAL DIAPHRAGM; CRURAL DIAPHRAGM; PULMONARY MECHANICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Wait et al., "DIAPHRAGM THICKNESS HETEROGENEITY AT FUNCTIONAL RESIDUAL CAPACITY ANDTOTAL LUNG CAPACITY", Journal of applied physiology, 78(3), 1995, pp. 1030-1036

Abstract

One of the determinants of muscular force is the number of myofibrilsin parallel, which is approximated by thickness. To better understandthe heterogeneity of diaphragm thickness, we quantified the interregional and radial patterns of thickness of nine canine diaphragms rapidly perfusion fixed in situ with glutaraldehyde at functional residual capacity (FRC) (n = 6) and total lung capacity (TLC) (n = 3). Thicknesswas determined gravimetrically from punch biopsies radiating from thecentral tendon to rib cage insertion in ventral, middle, and dorsal costal and crural regions. For comparison, the contralateral unfixed hemidiaphragm was sampled in the same fashion. The findings of this investigation include the following. 1)The costal diaphragm exhibits the same pattern of interregional heterogeneity at FRC, TLC, and in the freshly excised state. 2) The costal diaphragm is significantly thinner at FRC in situ (0.17 +/- 0.01 cm) than is the freshly excised contralateral diaphragm (0.21 +/- 0.01 cm; P < 0.05), whereas there is no significant difference between thickness at TLC and the freshly excised state. 3) There is significant, previously undescribed, radial tapering from the rib cage attachment (0.24 +/- 0.02 cm) to the central tendon insertion (0.15 +/- 0.01 cm; P < 0.05) that is exaggerated at TLC. 4) With passive inflation from FRC to TLC, the greatest increase in thickness occurs close to the rib cage attachment for the ventral and medialcostal regions but close to the central tendon in the dorsal and crural regions. We conclude that the diaphragm at FRC and TLC exhibits radial thickness heterogeneity that cannot, be predicted from dimensions of the freshly excised diaphragm. The thicker areas are predicted to either develop greater maximum force generation or lower wall stress for the same degree of activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:20:22