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Titolo:
EFFECT OF COMBINED TREATMENT WITH GONADOTROPIN-RELEASING-HORMONE ANALOG AND GROWTH-HORMONE IN PATIENTS WITH CENTRAL PRECOCIOUS PUBERTY WHO HAD SUBNORMAL GROWTH VELOCITY AND IMPAIRED HEIGHT PROGNOSIS
Autore:
SAGGESE G; PASQUINO AM; BERTELLONI S; BARONCELLI GI; BATTINI R; PUCARELLI I; SEGNI M; FRANCHI G;
Indirizzi:
UNIV PISA,DEPT PEDIAT,CHAIR PREVENT PEDIAT,ENDOCRINE UNIT,VIA ROMA 17I-56125 PISA ITALY UNIV ROME,DEPT PEDIAT,ENDOCRINE UNIT ROME ITALY
Titolo Testata:
Acta paediatrica
fascicolo: 3, volume: 84, anno: 1995,
pagine: 299 - 304
SICI:
0803-5253(1995)84:3<299:EOCTWG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEX STEROID-SECRETION; FACTOR-I; SHORT STATURE; GNRH ANALOG; CHILDREN; DEFICIENCY; GIRLS; AGONIST; THERAPY; SUPPRESSION;
Keywords:
CENTRAL PRECOCIOUS PUBERTY; GN-RH ANALOG TREATMENT; GROWTH HORMONE; GROWTH VELOCITY; PREDICTED ADULT HEIGHT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
G. Saggese et al., "EFFECT OF COMBINED TREATMENT WITH GONADOTROPIN-RELEASING-HORMONE ANALOG AND GROWTH-HORMONE IN PATIENTS WITH CENTRAL PRECOCIOUS PUBERTY WHO HAD SUBNORMAL GROWTH VELOCITY AND IMPAIRED HEIGHT PROGNOSIS", Acta paediatrica, 84(3), 1995, pp. 299-304

Abstract

Growth hormone-insulin-like growth factor-I status and response to growth hormone therapy (0.6IU/kg/week sc, six times a week for 12 months) were evaluated in 12 girls (chronological age 9.4 +/- 1.6 years) suffering from central precocious puberty with growth velocity less than 4 cm/year and no substantial increase or decrease in predicted adult height during gonadotropin releasing hormone (Gn-RH) analogue treatment(D-Trp(6)-LH-RH, 60 mu g/kg im/28 days). At baseline, large variationswere observed in nocturnal growth hormone (GH) means (pathological values (< 3.6 mu g/l) 33.3%), stimulated levodopa GH peaks (pathologicalvalues (<10.0 mu g/l) 28.6%) and serum insulin-like growth factor-I (IGF-I) levels. Neither GH nor IGF-I levels were correlated with growthvelocity. During recombinant GH therapy, growth velocity increased significantly (baseline 3.0 +/- 0.9 cm/year; 6 months 6.4 +/- 1.9 cm/year, p < 0.001 versus baseline; 12 months 6.0 +/- 1.3 cm/year, p < 0.001versus baseline). There was a significant increase in height SDS for bone age (baseline -1.6 +/- 0.5 SDS; 12 months -1.04 +/- 0.6 SDS; p < 0.002) and in predicted adult height (baseline 152.0 +/- 3.6 cm; 12 months 155.9 +/- 3.4 cm; p < 0.002). Our results suggest that combined therapy with Gn-RH analogues and recombinant GH can improve growth velocity and predicted adult height in girls with central precocious puberty and impaired height prognosis during Gn-RH analogue treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:06:59