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Titolo:
MOTHER-TO-INFANT TRANSMISSION OF HEPATITIS-C VIRUS
Autore:
RESTI M; AZZARI C; LEGA L; ROSSI ME; ZAMMARCHI E; NOVEMBRE E; VIERUCCI A;
Indirizzi:
UNIV FLORENCE,DEPT PEDIAT,VIA LUCA GIORDANO 13 I-50132 FLORENCE ITALY
Titolo Testata:
Acta paediatrica
fascicolo: 3, volume: 84, anno: 1995,
pagine: 251 - 255
SICI:
0803-5253(1995)84:3<251:MTOHV>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; NON-B HEPATITIS; VERTICAL TRANSMISSION; HCV-RNA; NON-A; INFECTION; SEQUENCES; COCAINE; WOMEN; PCR;
Keywords:
HCV; PCR; VERTICAL TRANSMISSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. Resti et al., "MOTHER-TO-INFANT TRANSMISSION OF HEPATITIS-C VIRUS", Acta paediatrica, 84(3), 1995, pp. 251-255

Abstract

Anti-hepatitis C virus (HCV) antibodies and HCV-RNA were measured in the sera of 22 anti-HCV positive, HIV-1 negative mothers and their infants. ELISA and RIBA II were used for anti-HCV determination. HCV-RNA was measured by a nested polymerase chain reaction. HCV-RNA was found in 12 of 22 mothers. All 22 children were followed for 12 months. All were anti-HCV positive by the fourth month; 18 became anti-HCV negative between the 8th and 12th month. HCV-RNA was detected in 5 of 22 infants in the fourth month. They remained HCV-RNA positive. All children born to HCV-RNA negative mothers were HCV-RNA negative while 5 of 12 babies born to HCV-RNA positive mothers were infected. All five infected babies were born to mothers infected through transfusions or drug use. ALT levels in mothers seemed to have no effect on mother-to-infant transmission. Hence evidence for perinatal transmission of HCV from HCV-RNA positive mothers was demonstrated in the present study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 04:22:44