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Titolo:
PROPHENIN-1, AN EXCEPTIONALLY PROLINE-RICH ANTIMICROBIAL PEPTIDE FROMPORCINE LEUKOCYTES
Autore:
HARWIG SSL; KOKRYAKOV VN; SWIDEREK KM; ALESHINA GM; ZHAO CQ; LEHRER RI;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,CTR HLTH SCI,DEPT MED,10833 LECONTE AVE LOS ANGELES CA 90095 INST EXPTL MED,DEPT GEN PATHOL & PATHOPHYSIOL ST PETERSBURG 19736 RUSSIA CITY HOPE NATL MED CTR,BECKMAN RES INST,DIV IMMUNOL DUARTE CA 91010 UNIV CALIF LOS ANGELES,SCH MED,CTR HLTH SCI,DEPT MED LOS ANGELES CA 90095
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 362, anno: 1995,
pagine: 65 - 69
SICI:
0014-5793(1995)362:1<65:PAEPAP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYSTEINE PROTEINASE-INHIBITOR; POLYACRYLAMIDE-GEL ELECTROPHORESIS; ANTIBACTERIAL PEPTIDES; ANTIBIOTIC DODECAPEPTIDE; BOVINE NEUTROPHILS; BIOACTIVE PEPTIDES; PIG LEUKOCYTES; PRO-SEQUENCE; CDNA; ACID;
Keywords:
ANTIMICROBIAL; CATHELIN; PEPTIDE; PORCINE LEUKOCYTE; PROLINE-RICH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S.S.L. Harwig et al., "PROPHENIN-1, AN EXCEPTIONALLY PROLINE-RICH ANTIMICROBIAL PEPTIDE FROMPORCINE LEUKOCYTES", FEBS letters, 362(1), 1995, pp. 65-69

Abstract

We purified and characterized an unusual antimicrobial peptide, prophenin-1 (PF-1), from porcine leukocytes. The peptide had a mass of 8,683 and contained 79 residues, including 42 (53.2%) prolines and 15 (19.0%) phenylalanines. Its N-terminal 60 residues consisted of three perfect and three nearly perfect repeats of a decamer, FPPPNFPGPR. Prophenin-1 was encoded on a cathelin-containing precursor and showed substantially more activity against E. coli, a Gram-negative bacterium, than against Lister ia monocytogenes, a Gram-positive organism, in vitro.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 05:46:16