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Titolo:
EFFECTS OF VERAPAMIL ON THE RELEASE OF DIFFERENT NEUROTRANSMITTERS
Autore:
SITGES M; REYES A;
Indirizzi:
INST MEXICANO PSIQUIATRIA,DIV INVEST CLIN,ANTIGUO CAMINO XOCHIMILCO 101 MEXICO CITY 14370 DF MEXICO NATL AUTONOMOUS UNIV MEXICO,INST INVEST BIOMED,DEPT BIOL MOLEC,PROGRAMA UNIV INVEST SALUD MEXICO CITY 04510 DF MEXICO
Titolo Testata:
Journal of neuroscience research
fascicolo: 5, volume: 40, anno: 1995,
pagine: 613 - 621
SICI:
0360-4012(1995)40:5<613:EOVOTR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-CHANNEL BLOCKERS; D1 DOPAMINE RECEPTOR; BINDING-SITES; AFFECTIVE-DISORDERS; ANTAGONISTS; EXPRESSION; MANIA; BRAIN; CLASSIFICATION; ANTIPSYCHOTICS;
Keywords:
STRIATAL; HIPPOCAMPAL; SYNAPTOSOMES; DOPAMINE; 5-HT; NOREPINEPHRINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Sitges e A. Reyes, "EFFECTS OF VERAPAMIL ON THE RELEASE OF DIFFERENT NEUROTRANSMITTERS", Journal of neuroscience research, 40(5), 1995, pp. 613-621

Abstract

The effect of verapamil on resting and depolarization-induced monoamine release was investigated in rat hippocampal synaptosomes prelabeledwith [H-3]-5-hydroxytryptamine (HT) or [H-3]-norepinephrine (NE) and rat striatal synaptosomes prelabeled with [H-3]-dopamine (DA), Verapamil (50 mu M) completely abolishes high K+-induced [H-3]-NE release, but paradoxically facilitates high K+-induced [H-3]-5-HT and [H-3]-DA release, All these high K+-evoked responses were Ca2+ dependent. Verapamil does not modify [H-3]-NE baseline release, but increases dose dependently [H-3]-5-HT and [H-3]-DA baseline release. Verapamil (10 mu M, for 5 min) increases endogenous DA release (70%) and endogenous 5-HT release (40%) independently on the presence of external Ca2+. The total amount of these monoamines (released plus retained by the preparation)and their metabolites (DOPAC and 5-HIAA) was similar in control and verapamil-treated synaptosomes. Verapamil displaces [H-3]-spiroperidol specific binding (K-i of 2.4 x 10(-6) M) and [H-3]-SCH-23390 specific binding (K-i of 9 x 10(-6) M) from striatal synaptosomal membranes, and [H-3]-5-HT specific binding (K-i of 3 x 10(-5) M) from hippocampal synaptosomal membranes, It is concluded that in addition to the Ca2+ antagonistic properties of verapamil on the Ca2+-dependent, depolarization-induced release of some neurotransmitters [gamma aminobutyric acid (GABA and NE)I, another mechanism probably mediated by presynaptic receptors underlies the effects of verapamil on DA and 5-HT release from discrete brain regions. (c) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:26:02