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Titolo:
ROLE OF PROSTAGLANDIN IN THE FORMATION OF OSTEOCLASTS INDUCED BY CAPSULAR-LIKE POLYSACCHARIDE ANTIGEN OF ACTINOBACILLUS-ACTINOMYCETEMCOMITANS STRAIN Y4
Autore:
UEDA N; NISHIHARA T; ISHIHARA Y; AMANO K; KUROYANAGI T; NOGUCHI T;
Indirizzi:
AICHI GAKUIN UNIV,SCH DENT,DEPT PERIODONTOL,CHIKUSA KU NAGOYA AICHI 464 JAPAN AICHI GAKUIN UNIV,SCH DENT,DEPT PERIODONTOL,CHIKUSA KU NAGOYA AICHI 464 JAPAN NATL INST HLTH,DEPT ORAL SCI TOKYO 141 JAPAN
Titolo Testata:
Oral microbiology and immunology
fascicolo: 2, volume: 10, anno: 1995,
pagine: 69 - 75
SICI:
0902-0055(1995)10:2<69:ROPITF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MACROPHAGE INTERLEUKIN-1 RELEASE; HUMAN PERIODONTAL-DISEASE; BONE-RESORPTION; HAEMOPHILUS-ACTINOMYCETEMCOMITANS; BACTEROIDES-GINGIVALIS; CELL-FORMATION; LIPOPOLYSACCHARIDE; CULTURES; INVITRO; ADENOSINE-3',5'-MONOPHOSPHATE;
Keywords:
ACTINOBACILLUS ACTINOMYCETEMCOMITANS; CAPSULAR-LIKE POLYSACCHARIDE ANTIGEN; BONE RESORPTION; PROSTAGLANDIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
N. Ueda et al., "ROLE OF PROSTAGLANDIN IN THE FORMATION OF OSTEOCLASTS INDUCED BY CAPSULAR-LIKE POLYSACCHARIDE ANTIGEN OF ACTINOBACILLUS-ACTINOMYCETEMCOMITANS STRAIN Y4", Oral microbiology and immunology, 10(2), 1995, pp. 69-75

Abstract

We found no reports that capsular-like polysaccharide antigen purified from Actinobacillus actinomycetemcomitans either induces osteoclastic bone resorption in mouse organ cultures or promotes osteoclast formation in mouse marrow cultures. In contrast, capsular-like polysaccharide antigen purified from A. actinomycetemcomitans strain Y4 induced bone resorption in mouse organ culture. To examine the mechanism of boneresorption induced by A. actinomycetemcomitans, mouse bone marrow cells were cultured with A. actinomycetemcomitans strain Y4 capsular-likepolysaccharide antigen. A. actinomycetemcomitans strain Y4 capsular-like polysaccharide antigen stimulated osteoclast-like cell formation in mouse bone marrow cultures. However, the polysaccharide of A. actinomycetemcomitans lipopolysaccharide did not induce the formation of osteoclastlike cells. Indomethacin inhibited osteoclast-like cell formation mediated by A. actinomycetemcomitans strain Y4 capsular-like polysaccharide antigen in a dose-dependent manner, There was a good correlation between the number of osteoclast-like cells formed in the marrow culture and the amount of prostaglandin E(2) released into the culture media. When mouse bone marrow cells were cultured with prostaglandin E(2) during the culture periods, many osteoclast-like cells were formed. These results indicate that prostaglandin E(2) is involved in the mechanism of the formation of osteoclast-like cells mediated by A. actinomycetemcomitans strain Y4 capsular-like polysaccharide antigen. A. actinomycetemcomitans strain Y4 capsular-like polysaccharide antigen mayplay an important role in inflammatory bone resorption by promoting osteoclast formation in periodontal disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:32:53