Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
POLYMODAL DOSE-RESPONSE CURVE FOR OXYTOCIN IN THE SOCIAL RECOGNITION TEST
Autore:
BENELLI A; BERTOLINI A; POGGIOLI R; MENOZZI B; BASAGLIA R; ARLETTI R;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,VIA G CAMPI 287 I-41100 MODENA ITALY
Titolo Testata:
Neuropeptides
fascicolo: 4, volume: 28, anno: 1995,
pagine: 251 - 255
SICI:
0143-4179(1995)28:4<251:PDCFOI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-MEMORY PROCESSES; NEUROHYPOPHYSEAL HORMONES; AVOIDANCE-BEHAVIOR; OPPOSITE ACTION; MALE-RATS; VASOPRESSIN; FRAGMENTS; MODULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Benelli et al., "POLYMODAL DOSE-RESPONSE CURVE FOR OXYTOCIN IN THE SOCIAL RECOGNITION TEST", Neuropeptides, 28(4), 1995, pp. 251-255

Abstract

Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigation time of the adult rat towards the same juvenile during a second encounter (120 min later) with two peaks of activity, at 10 fg and 1 ng/rat. Larger doses of oxytocin were ineffective. The oxytocin antagonist d(CH2)(5)Tyr(Me)-Orn(8)-vasotocin, injected 5 min before oxytocin by the same route and at the same doses, while being ineffective per se, completely abolished the memory-improving effect of a low dose of oxytocin (1 ng/rat) and, on the other hand, turned into memory-improving the effect of a high dose of oxytocin (500 ng/rat).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:39:33