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Titolo:
CELL VIABILITY AND LAMININ-INDUCED NEURITE OUTGROWTH IN CULTURES OF EMBRYONIC CHICK NEURAL-TUBE CELLS - EFFECTS OF CYTOSINE-B-D-ARABINOFURANOSIDE
Autore:
PARSON SH; PRICE JF; RIBCHESTER RR;
Indirizzi:
UNIV EDINBURGH,SCH MED,DEPT ANAT,TEVIOT PL EDINBURGH EH8 9AG MIDLOTHIAN SCOTLAND UNIV EDINBURGH,SCH MED,DEPT PUBL HLTH EDINBURGH EH8 9AG MIDLOTHIAN SCOTLAND UNIV EDINBURGH,SCH MED,DEPT PHYSIOL EDINBURGH EH8 9AG MIDLOTHIAN SCOTLAND
Titolo Testata:
Neurodegeneration
fascicolo: 1, volume: 4, anno: 1995,
pagine: 99 - 106
SICI:
1055-8330(1995)4:1<99:CVALNO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
KILLS POSTMITOTIC NEURONS; DNA-SYNTHESIS; TISSUE-CULTURE; ARABINOSIDE; DEOXYCYTIDINE; SURVIVAL; GROWTH; MUSCLE; NERVE; 1-BETA-D-ARABINOFURANOSYLCYTOSINE;
Keywords:
CHICK EMBRYO; CYTOSINE ARABINOSIDE; NEURONAL CULTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
S.H. Parson et al., "CELL VIABILITY AND LAMININ-INDUCED NEURITE OUTGROWTH IN CULTURES OF EMBRYONIC CHICK NEURAL-TUBE CELLS - EFFECTS OF CYTOSINE-B-D-ARABINOFURANOSIDE", Neurodegeneration, 4(1), 1995, pp. 99-106

Abstract

We have measured the effects of cytosine-beta-D-arabinofuranoside (AraC) on cell survival and neurite outgrowth in cultures of dissociated 4-6 day embryonic chick neural tube cells. High con centrations of AraC (greater than 100 mu M) reduced neuronal eel survival and neurite outgrowth from viable cells. Concentrations normally used to inhibit mitotic cell division (1-10 mu M) were toxic to the neurones cultured in serum free medium on a poly-DL-ornithine/laminin substrate. AraC does not appear to have a neurite promoting effect on dissociated neurones that are cultured in the presence of low numbers of non-neuronal cells. This suggests that the neurite promoting effects of AraC reported byothers is likely to be through the non-neuronal cells that were an inherent feature of the culturing systems in these studies. AraC cytotoxicity was completely blocked by the addition of the competitive antagonist: 2'deoxycytidine (2'DC) but not by its metabolic precursor cytosine (cyt). We suggest that the acute effects of AraC on neurones which are actively growing neurites are the result of interference with lipid metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:55:09