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Titolo:
ON THE NEUROPATHOLOGY OF SCHIZOPHRENIA AND ITS DEMENTIA - NEURODEVELOPMENTAL, NEURODEGENERATIVE, OR BOTH
Autore:
HARRISON PJ;
Indirizzi:
UNIV OXFORD,WARNEFORD HOSP,DEPT PSYCHIAT OXFORD OX3 7JX ENGLAND RADCLIFFE INFIRM,DEPT NEUROPATHOL OXFORD OX2 6HE ENGLAND
Titolo Testata:
Neurodegeneration
fascicolo: 1, volume: 4, anno: 1995,
pagine: 1 - 12
SICI:
1055-8330(1995)4:1<1:OTNOSA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYLVIAN FISSURE ASYMMETRY; MINOR PHYSICAL ANOMALIES; CAVUM-SEPTUM-PELLUCIDUM; CENTRAL-NERVOUS-SYSTEM; TEMPORAL-LOBE; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; BASAL GANGLIA; PARAHIPPOCAMPAL GYRUS; CORTICAL DEVELOPMENT;
Keywords:
ALZHEIMERS DISEASE; ASTROCYTE; DEMENTIA; GLIOSIS; PSYCHOSIS; SCHIZOPHRENIA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
137
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Harrison, "ON THE NEUROPATHOLOGY OF SCHIZOPHRENIA AND ITS DEMENTIA - NEURODEVELOPMENTAL, NEURODEGENERATIVE, OR BOTH", Neurodegeneration, 4(1), 1995, pp. 1-12

Abstract

The neuropathology of schizophrenia has begun to emerge following renewed investigation in the past 20 years. However, there remain inconsistencies in the data and their interpretation. In particular, althoughthe brains of schizophrenics have been reported to show an excess of neurodegenerative changes, especially astrocytic gliosis and Alzheimer's disease, it is unclear whether these features are an intrinsic partof the neuropathology of schizophrenia. Nor is it apparent how they relate to the symptoms of dementia which afflict a proportion of schizophrenics. This review focuses upon these questions. Two main conclusions are drawn. Firstly, the neuropathological features of schizophreniatogether support a neurodevelopmental pathogenesis wherein the aforementioned degenerative changes are either epiphenomenal, artefactual, or are limited to a subgroup of cases which are otherwise indistinguishable clinically or pathologically. Secondly, the dementia of schizophrenia is not attributable to Alzheimer's disease nor to any other recognized neuropathological substrate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:20:02