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Titolo:
GENETIC INFLUENCE ON CYTOKINE PRODUCTION AND FATAL MENINGOCOCCAL DISEASE
Autore:
WESTENDORP RGJ; LANGERMANS JAM; HUIZINGA TWJ; ELOUALI AH; VERWEIJ CL; BOOMSMA DI; VANDENBROUKE JP;
Indirizzi:
UNIV LEIDEN HOSP,DEPT CLIN EPIDEMIOL,CO-P NL-2300 RC LEIDEN NETHERLANDS UNIV LEIDEN HOSP,DEPT GEN INTERNAL MED NL-2300 RC LEIDEN NETHERLANDS UNIV LEIDEN HOSP,DEPT INFECT DIS NL-2300 RC LEIDEN NETHERLANDS UNIV LEIDEN HOSP,DEPT RHEUMATOL NL-2300 RC LEIDEN NETHERLANDS FREE UNIV AMSTERDAM,DEPT PSYCHONOM AMSTERDAM NETHERLANDS
Titolo Testata:
Lancet
fascicolo: 9046, volume: 349, anno: 1997,
pagine: 170 - 173
SICI:
0140-6736(1997)349:9046<170:GIOCPA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; TNF-ALPHA; PEDIGREE ANALYSIS; PROMOTER; RELEASE; DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
R.G.J. Westendorp et al., "GENETIC INFLUENCE ON CYTOKINE PRODUCTION AND FATAL MENINGOCOCCAL DISEASE", Lancet, 349(9046), 1997, pp. 170-173

Abstract

Background To assess the genetic influence on cytokine production andits contribution to fatal outcome, we determined the capacity to produce tumour necrosis factor-alpha (TNF alpha) and interleukin-10 (IL-10) in families of patients who had had meningococcal disease. Methods We studied 190 first-degree relatives of 61 patients with meningococcaldisease; we also studied 26 monozygotic twins. Production of cytokines was determined during endotoxin stimulation of whole-blood samples ex-vivo. Heritability was estimated in a pedigree-based maximum-likelihood model. DNA was typed for the G to A transition polymorphisms at position -308 and -238 in the TNF gene promoter. Findings Heritability in monozygotic twins was 0 . 60 for the production of TNF and 0 . 75 for the production of IL-10, Families with low TNF production had a tenfold increased risk for fatal outcome (OR 8 . 9, 95% Cl 1 . 8-45), whereas high IL-10 production increased the risk 20-fold (19 . 5, 2 . 3-165). Families with both characteristics had the greatest risk. The transition polymorphisms in the TNF gene promoter were not associated withoutcome. Interpretation Genetic factors substantially influence production of cytokines. An innate anti-inflammatory cytokine profile may contribute to fatal meningococcal disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:58:43