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Titolo:
MYCOBACTERIA-INDUCED AUTOANTIBODY PRODUCTION IS ASSOCIATED WITH SUSCEPTIBILITY TO INFECTION BUT NOT WITH HOST PROPENSITY TO DEVELOP AUTOIMMUNE-DISEASE
Autore:
BRAS A; AGUAS AP;
Indirizzi:
UNIV OPORTO,CTR EXPTL CYTOL,RUA CAMPO ALEGRE 823 P-4100 OPORTO PORTUGAL UNIV OPORTO,CTR EXPTL CYTOL P-4100 OPORTO PORTUGAL UNIV OPORTO,ABEL SALAZAR INST BIOMED SCI,DEPT ANAT P-4100 OPORTO PORTUGAL
Titolo Testata:
Clinical and experimental immunology
fascicolo: 1, volume: 100, anno: 1995,
pagine: 75 - 80
SICI:
0009-9104(1995)100:1<75:MAPIAW>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-RESISTANCE; MACROPHAGE ACTIVATION; NORMAL MICE; CELLS; PROTEIN; IMMUNOSUPPRESSION; ANTIBODIES; BCG;
Keywords:
AUTOANTIBODIES; IMMUNOSUPPRESSION; MYCOBACTERIUM AVIUM; POLYCLONAL B CELL; ACTIVATION; INTERFERON-GAMMA; T CELL-DEPENDENT ANTIGEN; AUTOIMMUNITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A. Bras e A.P. Aguas, "MYCOBACTERIA-INDUCED AUTOANTIBODY PRODUCTION IS ASSOCIATED WITH SUSCEPTIBILITY TO INFECTION BUT NOT WITH HOST PROPENSITY TO DEVELOP AUTOIMMUNE-DISEASE", Clinical and experimental immunology, 100(1), 1995, pp. 75-80

Abstract

Mycobacteria cause increase in autoantibody production in the host during the first weeks of infection. The level of the autoantibody enhancement varies widely in different hosts, suggesting that it depends onfeatures of the host make-up. We have investigated the participation of two characteristics of the host in the modulation of mycobacteria-induced autoantibody production: (i) the host being genetically determined to later develop spontaneous autoimmune disease; (ii) the host being susceptible/resistant to mycobacterial infection. Mycobacterium avium infection was studied in 3-month-old mice that are prone (NZB and C57B1/6-lpr/lpr strains) or not (NZW and C.D2 strains) to develop, whenolder, autoimmune disease; these murine strains are either naturally susceptible (C57B1/6-lpr/lpr and NZW) or resistant (NZB and C.D2) to mycobacteria. Mycobacterium avium infection was produced by i.p. injection of 3 x 10(7) viable bacilli. At days 15 and 30 of the infection, we determined the following parameters: (i) number of cells producing natural autoantibodies (splenic cells showing surface antibodies against bromelain-treated mouse (BrM) erythrocytes); (ii) suppression of theprimary response to T cell-dependent antigen (i.e. to sheep erythrocytes); (iii) immunoglobulin classes and IgG isotypes; (iv) titres of anti-dsDNA antibodies; and (v) serum concentrations of interferon-gamma (IFN-gamma). We found that the highest elevations in natural autoantibodies were associated with hosts being naturally susceptible to mycobacteria, but not with the host being genetically determined to later develop autoimmune disease. The rise in autoantibodies was predominantlyof the IgM type, being associated with suppression of the T cell response and accompanied by increase in serum IFN-gamma. Mycobacteria failed to induce any significant enhancement in pathogenic anti-dsDNA antibodies. Our data suggest that the finding of a high level of autoantibodies during the early phase of mycobacterial infection reflects host susceptibility to the infectious agent, and that it is not related with its propensity to later develop autoimmune disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:43:48