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Titolo:
INTERACTION OF MAGNESIUM-SULFATE WITH VECURONIUM-INDUCED NEUROMUSCULAR BLOCK
Autore:
FUCHSBUDER T; WILDERSMITH OHG; BORGEAT A; TASSONYI E;
Indirizzi:
UNIV HOSP GENEVA,DEPT ANAESTHESIOL,14 RUE MICHELI DU CREST 24 CH-1211GENEVA SWITZERLAND
Titolo Testata:
British Journal of Anaesthesia
fascicolo: 4, volume: 74, anno: 1995,
pagine: 405 - 409
SICI:
0007-0912(1995)74:4<405:IOMWVN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE-RESPONSE CURVES; ANESTHESIA; HYPERMAGNESEMIA; SUCCINYLCHOLINE; SEQUENCE;
Keywords:
NEUROMUSCULAR BLOCK, VECURONIUM; IONS, MAGNESIUM SULFATE; MEASUREMENT TECHNIQUES, ELECTROMYOGRAPHY; PHARMACOLOGY, DOSE-RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
T. Fuchsbuder et al., "INTERACTION OF MAGNESIUM-SULFATE WITH VECURONIUM-INDUCED NEUROMUSCULAR BLOCK", British Journal of Anaesthesia, 74(4), 1995, pp. 405-409

Abstract

We have investigated the interaction between magnesium sulphate 40 mgkg(-1) i.v. and vecuronium. First, we determined the effect of pretreatment with magnesium on the potency of vecuronium using a single bolus dose-response technique. In addition, we compared the time course ofvecuronium-induced neuromuscular block (vecuronium 100 mu g kg(-1)) with and without magnesium pretreatment. For both parts, neuromuscular block was assessed by electromyography. In addition, the effect of magnesium pretreatment on vecuronium-induced neuromuscular block was investigated in the context of rapid sequence induction of anaesthesia. Wefound that the neuromuscular potency of vecuronium was increased by pretreatment with magnesium sulphate. The ED(50) and ED(90) of vecuronium with MgSO4 were 25% lower than MgSO4 (ED(50): vs 26.9 mu g kg(-1); 34.2 vs 45.7 mu g kg(-1); P < 0.05 for both). Mean onset time was 147.3 (SD 22.2) s in the MgSO4-vecuronium group vs 297.3 (122) s for controls (P < 0.05). Clinical duration was prolonged (MgSO4-vecuronium 43.3(9) min vs 25.2 (5.1) min for controls; P < 0.05). This was also truefor the recovery index (20.1 (6.6) min vs 10.6 (3.4) min; P < 0.05) and duration to 75% recovery (63.4 (9.9) min vs 35.8 (6.9) min; P < 0.05). in the context of rapid sequence induction, pretreatment with MgSO4 improved the intubating score of vecuronium compared with vecuroniumwithout MgSO4, reaching the same quality as that with suxamethonium 1mg kg(-1). We conclude that magnesium pretreatment increased the neuromuscular potency of vecuronium, in addition to modifying the time course of its neuromuscular block.

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Documento generato il 30/09/20 alle ore 09:36:35