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Titolo:
A DELETION MUTANT OF THE LMP1 ONCOGENE OF EPSTEIN-BARR-VIRUS IS ASSOCIATED WITH EVOLUTION OF ANGIOIMMUNOBLASTIC LYMPHADENOPATHY INTO B-IMMUNOBLASTIC LYMPHOMA
Autore:
KNECHT H; MARTIUS F; BACHMANN E; HOFFMAN T; ZIMMERMANN DR; ROTHENBERGER S; SANDVEJ K; WEGMANN W; HURWITZ N; ODERMATT BF; KUMMER H; PALLESEN G;
Indirizzi:
UNIV MASSACHUSETTS,MED CTR,DEPT MED,DIV HEMATOL ONCOL,55 LAKE AVE N WORCESTER MA 01655 UNIV LAUSANNE HOSP,CHU VAUDOIS,DEPT INTERNAL MED LAUSANNE SWITZERLAND UNIV BASEL,HOSP BRUDERHOLZ,MED CLIN BASEL SWITZERLAND UNIV BASEL,HOSP BRUDERHOLZ,INST PATHOL BASEL SWITZERLAND AARHUS KOMMUNE HOSP,IMMUNOPATHOL LAB DK-8000 AARHUS DENMARK UNIV ZURICH HOSP,DEPT PATHOL CH-8091 ZURICH SWITZERLAND
Titolo Testata:
Leukemia
fascicolo: 3, volume: 9, anno: 1995,
pagine: 458 - 465
SICI:
0887-6924(1995)9:3<458:ADMOTL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATENT MEMBRANE-PROTEIN; REED-STERNBERG CELLS; POLYMERASE CHAIN-REACTION; HODGKINS-DISEASE; NASOPHARYNGEAL CARCINOMA; T-CELLS; INSITU HYBRIDIZATION; TRANSIENT EXPRESSION; MALIGNANT-LYMPHOMA; FREQUENT DETECTION;
Keywords:
ANGIOIMMUNOBLASTIC LYMPHADENOPATHY; IMMUNOBLASTIC LYMPHOMA; LMP1; ONCOGENE; MALIGNANT TRANSFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
H. Knecht et al., "A DELETION MUTANT OF THE LMP1 ONCOGENE OF EPSTEIN-BARR-VIRUS IS ASSOCIATED WITH EVOLUTION OF ANGIOIMMUNOBLASTIC LYMPHADENOPATHY INTO B-IMMUNOBLASTIC LYMPHOMA", Leukemia, 9(3), 1995, pp. 458-465

Abstract

The latent membrane protein 1 (LMP1) oncogene is one of the major proteins synthesized by the Epstein-Barr virus (EBV). It is expressed in Reed-Sternberg cells of Hodgkin's disease (HD), tumor cells of nasopharyngeal carcinoma (NPC), and immunoblasts of angioimmunoblastic lymphadenopathy (AILD). A particular LMP1 deletion mutant was recently identified in NPC and clinically and histologically aggressive HD. We studied two patients with AILD that subsequently progressed into immunoblastic lymphoma (IBL) in order to investigate whether this LMP1 deletion mutant was implicated in progression of AILD into IBL. Immunohistologyand in situ hybridization were performed on diagnostic biopsies. DNA extracted from fresh frozen material was used for rearrangement studies and polymerase chain reaction (PCR) based amplification and sequencing of portions of the LMP1 gene. Immunohistochemistry revealed B cell origin of both cases of IBL. In the first patient clonal rearrangementof the immunoglobulin heavy-chain gene was present in IBL but not in AILD. In this patient, scattered immunoblasts of AILD and numerous tumor cells of B-IBL were shown to contain EBV transcripts (EBER1) and toexpress LMP1. Sequence analysis of the LMP1 gene from AILD and IBL inthe first, and from IBL in the second patient, revealed identical deletions and point mutations. This LMP1 deletion mutant is identical to those which have been reported in HD and NPC. Its association with evolution of AILD into B-IBL, aggressive HD and NPC, suggests that this particular mutant is more widespread than originally thought and is clinically relevant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 05:29:15