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Titolo:
5-CARBOXAMIDOTRYPTAMINE ATTENUATES THE DEVELOPMENT OF DEOXYCORTICOSTERONE ACETATE-SALT HYPERTENSION IN RATS
Autore:
BALASUBRAMANIAM G; LEE HS; MAH SC;
Indirizzi:
NATL UNIV SINGAPORE,FAC MED,DEPT PHARMACOL,10 KENT RIDGE CRESCENT SINGAPORE 0511 SINGAPORE NATL UNIV SINGAPORE,FAC MED,DEPT PHARMACOL SINGAPORE 0511 SINGAPORE CIBA GEIGY LTD,DEPT MED & CLIN DEV BASEL SWITZERLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 1-2, volume: 276, anno: 1995,
pagine: 183 - 190
SICI:
0014-2999(1995)276:1-2<183:5ATDOD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1-LIKE RECEPTOR; VENA-CAVA; AGONIST; 5-HT1A; 5-HYDROXYTRYPTAMINE; RESPONSIVENESS; VASOPRESSIN; RESISTANT; KIDNEY;
Keywords:
5-CARBOXAMIDOTRYPTAMINE; DOCA-SALT (DEOXYCORTICOSTERONE ACETATE-SALT) HYPERTENSIVE RAT; BLOOD PRESSURE; BAROREFLEX SENSITIVITY; (CHRONIC IV INFUSION);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
G. Balasubramaniam et al., "5-CARBOXAMIDOTRYPTAMINE ATTENUATES THE DEVELOPMENT OF DEOXYCORTICOSTERONE ACETATE-SALT HYPERTENSION IN RATS", European journal of pharmacology, 276(1-2), 1995, pp. 183-190

Abstract

The effect of chronic i.v. infusion of the 5-HT1 receptor agonist, 5-carboxamidotryptamine (5-CT), was evaluated during the development of deoxycorticosterone acetate-salt (DOCA-salt) hypertension in rats over4 weeks. Vehicle-treated (n = 10) Sprague-Dawley rats given DOCA (100mg/kg, s.c.) and 1% saline as drinking fluid developed hypertension with systolic blood pressure reaching 194.6 +/- 8.99 mm Hg at 27 days. In DOCA-salt rats treated with 5-CT infusions (15.0 mu g/kg per day, n= 10) for 4 weeks via osmotic minipumps, systolic blood pressure was significantly lower by 41.7 mm Hg at day 27 when compared to vehicle-treated DOCA-salt rats. Systolic blood pressure values on day 27 in 5-CT-treated DOCA-salt rats were however greater than those in vehicle-treated control rats which were not given DOCA. Systolic blood pressure in 5-CT-treated DOCA-salt rats was significantly lower by day 7 compared to vehicle-treated DOCA-salt rats and remained lowered for the restof the observation period. Heart rate was significantly greater in 5-CT-treated DOCA-salt rats on day 7 when compared to vehicle-treated DOCA-salt rats. Baroreflex sensitivity on day 28 was significantly greater in 5-CT-treated DOCA-salt rats as compared to vehicle-treated DOCA-salt rats. On day 28, hypotensive responses to hexamethonium (20 mg/kg) in 5-CT-treated DOCA-salt rats were markedly reduced compared to those in vehicle-treated DOCA-salt rats. The data suggest that chronic administration of 5-CT attenuates the development of DOCA-salt hypertension in rats with concomitant attenuation of the dampening of baroreflex sensitivity seen during the development of hypertension. The resultsalso suggest a peripheral sympathoinhibitory action of 5-CT in addition to the known peripheral vasodilatation via 5-HT1 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:31:37