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Titolo: DIFFERENTIAL EXPRESSION OF BETA1, BETA3 AND BETA4 INTEGRINS IN SARCOMAS OF THE SMALL, ROUND, BLUE CELL CATEGORY
Autore: BARTH T; MOLLER P; MECHTERSHEIMER G;
 Indirizzi:
 UNIV HEIDELBERG,INST PATHOL,NEUENHEIMER FELD 220 D69120 HEIDELBERG GERMANY UNIV HEIDELBERG,INST PATHOL D69120 HEIDELBERG GERMANY
 Titolo Testata:
 Virchows Archiv
fascicolo: 1,
volume: 426,
anno: 1995,
pagine: 19  25
 SICI:
 09456317(1995)426:1<19:DEOBBA>2.0.ZU;2S
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 MONOCLONALANTIBODIES; EWINGSSARCOMA; PERIPHERAL NEUROEPITHELIOMA; NEUROECTODERMAL TUMORS; SURFACEANTIGENS; TCELLS; LINES; RECEPTORS; BINDING; ASSOCIATION;
 Keywords:
 SMALL ROUND BLUE CELL SARCOMAS; INTEGRINS; IMMUNOHISTOCHEMISTRY;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Science Citation Index Expanded
 Citazioni:
 45
 Recensione:
 Indirizzi per estratti:



 Citazione:
 T. Barth et al., "DIFFERENTIAL EXPRESSION OF BETA1, BETA3 AND BETA4 INTEGRINS IN SARCOMAS OF THE SMALL, ROUND, BLUE CELL CATEGORY", Virchows Archiv, 426(1), 1995, pp. 1925
Abstract
Integrins are a large and complex family of membrane spanning alpha beta heterodimeric cell surface glycoproteins mediating cell/cell and cell/matrix interactions. Small, round, blue cell sarcomas (SRBCS) are a group of poorly differentiated tumours of various and in part uncertain histogenesis displaying similar cytomorphology. Among them are rhabdomyosarcomas (RMS), ganglioneuroblastomas [(G)NB], primitive peripheral neuroectodermal tumours (pPNET) and Ewing's sarcomas (ES). Thirtytwo SRBCS were studied immunohistochemically for the distribution of beta 1, beta 3 and beta 4 integrins in situ. We found complex and to some extent differential patterns of beta 1, beta 3 and beta 4 integrin subunit expression in different types of SRBCS: all of the sarcomas studied were consistently beta 1(+), beta 4(), alpha 2(). Four of nineRMS were completely negative for all other integrin subunits studied while one RMS was alpha 5(+) throughout and three RMS were focally alpha 5(+). Three RMS expressed the alpha 6 and alpha v chains. In contrast to RMS, pPNET and ES, all of which were alpha 1(), alpha 3(), (G)NB were alpha 3(+) and frequently coexpressed alpha 1. The eight pPNET and seven ES studied showed a similarily restricted integrin profilethat was limited to the expression of beta 1 and alpha 5 in nearly all cases. In summary, RMS were beta 1(+), alpha 1(), alpha 3() and heterogeneously expressed alpha 5 and alpha 6. (G)NB were generally beta1(+), alpha 1(+), alpha 3(+), alpha 5(), alpha 6(). pPNET and ES were beta 1(+), alpha 1(), alpha 3(), alpha 5(+), alpha 6(). The dataillustrate a complex expression pattern of various integrins in SRBCS, a differential expression pattern of some of the integrin subunits among different types of SRBCS and almost identical integrin profiles in pPNET and ES.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 10:32:46