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Titolo:
DIFFERENTIAL EXPRESSION OF BETA-1, BETA-3 AND BETA-4 INTEGRINS IN SARCOMAS OF THE SMALL, ROUND, BLUE CELL CATEGORY
Autore:
BARTH T; MOLLER P; MECHTERSHEIMER G;
Indirizzi:
UNIV HEIDELBERG,INST PATHOL,NEUENHEIMER FELD 220 D-69120 HEIDELBERG GERMANY UNIV HEIDELBERG,INST PATHOL D-69120 HEIDELBERG GERMANY
Titolo Testata:
Virchows Archiv
fascicolo: 1, volume: 426, anno: 1995,
pagine: 19 - 25
SICI:
0945-6317(1995)426:1<19:DEOBBA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; EWINGS-SARCOMA; PERIPHERAL NEUROEPITHELIOMA; NEUROECTODERMAL TUMORS; SURFACE-ANTIGENS; T-CELLS; LINES; RECEPTORS; BINDING; ASSOCIATION;
Keywords:
SMALL ROUND BLUE CELL SARCOMAS; INTEGRINS; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
T. Barth et al., "DIFFERENTIAL EXPRESSION OF BETA-1, BETA-3 AND BETA-4 INTEGRINS IN SARCOMAS OF THE SMALL, ROUND, BLUE CELL CATEGORY", Virchows Archiv, 426(1), 1995, pp. 19-25

Abstract

Integrins are a large and complex family of membrane spanning alpha beta heterodimeric cell surface glycoproteins mediating cell/cell and cell/matrix interactions. Small, round, blue cell sarcomas (SRBCS) are a group of poorly differentiated tumours of various and in part uncertain histogenesis displaying similar cytomorphology. Among them are rhabdomyosarcomas (RMS), ganglioneuroblastomas [(G)NB], primitive peripheral neuroectodermal tumours (pPNET) and Ewing's sarcomas (ES). Thirty-two SRBCS were studied immunohistochemically for the distribution of beta 1, beta 3 and beta 4 integrins in situ. We found complex and to some extent differential patterns of beta 1, beta 3 and beta 4 integrin subunit expression in different types of SRBCS: all of the sarcomas studied were consistently beta 1(+), beta 4(-), alpha 2(-). Four of nineRMS were completely negative for all other integrin subunits studied while one RMS was alpha 5(+) throughout and three RMS were focally alpha 5(+). Three RMS expressed the alpha 6 and alpha v chains. In contrast to RMS, pPNET and ES, all of which were alpha 1(-), alpha 3(-), (G)NB were alpha 3(+) and frequently co-expressed alpha 1. The eight pPNET and seven ES studied showed a similarily restricted integrin profilethat was limited to the expression of beta 1 and alpha 5 in nearly all cases. In summary, RMS were beta 1(+), alpha 1(-), alpha 3(-) and heterogeneously expressed alpha 5 and alpha 6. (G)NB were generally beta1(+), alpha 1(+), alpha 3(+), alpha 5(-), alpha 6(-). pPNET and ES were beta 1(+), alpha 1(-), alpha 3(-), alpha 5(+), alpha 6(-). The dataillustrate a complex expression pattern of various integrins in SRBCS, a differential expression pattern of some of the integrin subunits among different types of SRBCS and almost identical integrin profiles in pPNET and ES.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 10:32:46