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Titolo:
D-2-RECEPTOR IMAGING WITH [I-123] IBZM AND SINGLE-PHOTON EMISSION TOMOGRAPHY IN PSYCHIATRY - A SURVEY OF CURRENT STATUS
Autore:
SCHLOSSER R; SCHLEGEL S;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55131 MAINZ GERMANY
Titolo Testata:
Journal of neural transmission
fascicolo: 1-3, volume: 99, anno: 1995,
pagine: 173 - 185
SICI:
0300-9564(1995)99:1-3<173:DIW[IA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2-DOPAMINE RECEPTOR OCCUPANCY; DOPAMINE-RECEPTORS; I-123 IBZM; SCHIZOPHRENIC-PATIENTS; CLINICAL-RESPONSE; BRAIN SPECT; BLOCKADE; IODINE-123-IBZM; HYPOTHESIS; RACLOPRIDE;
Keywords:
SPECT; IBZM; DOPAMINE RECEPTORS; PSYCHIATRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
R. Schlosser e S. Schlegel, "D-2-RECEPTOR IMAGING WITH [I-123] IBZM AND SINGLE-PHOTON EMISSION TOMOGRAPHY IN PSYCHIATRY - A SURVEY OF CURRENT STATUS", Journal of neural transmission, 99(1-3), 1995, pp. 173-185

Abstract

D-2-dopamine receptors can be visualized in the human brain in vivo by Single Photon Emission Tomography (SPECT) and the radiolabeled benzamide [I-123]IBZM. The present paper reviews the current status of thistype of functional brain imaging with respect to basic methodologicalaspects, data analysis and quantification. The results from publishedclinical studies in different psychiatric patient populations and normal controls with [I-123]IBZM are reviewed. [I-123]IBZM-SPECT is a powerful tool for the investigation of D-2-dopamine receptor status in psychiatric disorders, different types of drug treatment as well as therapeutic and side effects of pharmacologic agents. However, there stillis a need for standardized imaging times and image-processing procedures. Advantages and disadvantages of SPECT with special regard to Positron Emission Tomography (PET) are also discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:29:39