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Titolo:
PREPARATION AND EVALUATION OF SODIUM DICLOFENAC CONTROLLED-RELEASE TABLETS .2. DIBASIC CALCIUM PHOSPHATE AS A RETARDENT IN MIXTURES FOR DIRECT COMPRESSION
Autore:
LIN SY; CHENG CL; LIN PC;
Indirizzi:
VET GEN HOSP,DEPT MED RES,BIOPHARMACEUT LAB TAIPEI 11217 TAIWAN
Titolo Testata:
Pharmacy world & science
fascicolo: 2, volume: 17, anno: 1995,
pagine: 42 - 47
SICI:
0928-1231(1995)17:2<42:PAEOSD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EUDRAGIT RESINS; COMPACTION; BEHAVIOR;
Keywords:
CALCIUM PHOSPHATES; DELAYED-ACTION PREPARATIONS; DICLOFENAC; DISSOLUTION; DRUG COMPOUNDING; TABLETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S.Y. Lin et al., "PREPARATION AND EVALUATION OF SODIUM DICLOFENAC CONTROLLED-RELEASE TABLETS .2. DIBASIC CALCIUM PHOSPHATE AS A RETARDENT IN MIXTURES FOR DIRECT COMPRESSION", Pharmacy world & science, 17(2), 1995, pp. 42-47

Abstract

The dissolution behaviour of a direct compression compact prepared with sodium diclofenac and dibasic calcium phosphate (DCP) in different weight ratios with or without Biosoluble polymer(R) (acrylic-based resin) was investigated io distilled water and in a medium with changing pH. The results indicate that the amount of sodium diclofenac releasedfrom the compact was dependent on the amount of drug and DCP used in the compact, and was also controlled by the amount of Biosoluble polymer(R) added. A chemical reaction forming diclofenac acid might occur on the surface of the sodium diclofenac compact during exposure to the acidic medium, which was confirmed by diffuse-reflectance spectroscopy. The tablet with a 1:2 weight ratio of sodium diclofenac to DCP exhibited a sustained-release behaviour, similar to commercial sustained-release products (Voltaren SR-100(R) and Grofenac Retard(R)), but a lower release rate was found as compared to the commercial products. The dissolution behaviour of the study table and the commercial products was found to be dependent on the dissolution medium and the rotating speeds. Class beads were added to the dissolution assembly to simulate the influence of food, and the enhanced friction between tablet and glass beads might result in a higher dissolution rate of the tablet and the commercial products.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 20:18:53