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Titolo:
SURGICAL TOUCH ARTIFACTS OF THE CEREBRAL-CORTEX - AN EXPERIMENTAL-STUDY WITH LIGHT AND ELECTRON-MICROSCOPIC ANALYSIS
Autore:
KEPES JJ; MALONE DG; GRIFFIN W; MORAL LA; YARDE WL; JONES S;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT PATHOL & LAB MED KANSAS CITY KS 66160 UNIV KANSAS,COLL HLTH SCI & HOSP,DEPT PATHOL & LAB MED KANSAS CITY KS00000 UNIV KANSAS,COLL HLTH SCI & HOSP,DEPT SURG,DIV NEUROSURG KANSAS CITY KS 00000
Titolo Testata:
Clinical neuropathology
fascicolo: 2, volume: 14, anno: 1995,
pagine: 86 - 92
SICI:
0722-5091(1995)14:2<86:STAOTC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Keywords:
CEREBRAL CORTEX; DARK NEURONS; HYDROPIC SWELLING; NEURONAL PYKNOSIS; PALE NEURONS; TOUCH ARTIFACTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Kepes et al., "SURGICAL TOUCH ARTIFACTS OF THE CEREBRAL-CORTEX - AN EXPERIMENTAL-STUDY WITH LIGHT AND ELECTRON-MICROSCOPIC ANALYSIS", Clinical neuropathology, 14(2), 1995, pp. 86-92

Abstract

In surgically excised brain tissue a very common artefact, unrelated to the presence or absence of a genuine pathological process, involvesthe water content of cortical neurons. Nerve cells may show massive watery swelling of bath their cytoplasm and nuclei or conversely may become shrunken and dark-staining. The most important aspect of this alteration is that it may lead to mistaken histopathological interpretation, but the question also arises whether such changes, presumably caused by exposure, touch, pressure or the combination of all 3, in the living patient, would persist after surgery and would eventually result in irreversible damage to the involved neurons? Thirty rats were operated in this experiment: craniotomy and opening of the dura mater was done over one convexity and slight pressure (uniformly calibrated for all animals) was applied to the exposed cortex. The wound was closed and the animals were sacrificed at various intervals, ranging from immediately after the operation to 6 weeks. The areas that suffered compression were examined by light and electron microscopy. Initial changes included marked watery swelling of neuronal perikarya and nuclei which predominated over pyknotic changes. The changes thus produced were identical with those seen in portions of the cortex excised immediately after pressure was applied to the area in 10 additional rats. After 3 weeks, only pyknotic changes were encountered and at the end of 6 weeks, practically all changes have resolved. There was no indication that any of the affected cells died from this process but it seems likely that neurons bath in the overhydrated (swollen) and the pyknotic phase function in a less than optimal manner.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 10:52:05