Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ROLE OF INTERFERON-GAMMA IN MEDIATING THE ANTITUMOR EFFICACY OF INTERLEUKIN-12
Autore:
BRUNDA MJ; LUISTRO L; HENDRZAK JA; FOUNTOULAKIS M; GAROTTA G; GATELY MK;
Indirizzi:
HOFFMANN LA ROCHE INC,DEPT ONCOL,340 KINGSLAND ST NUTLEY NJ 07110 HOFFMANN LA ROCHE INC,DEPT INFLAMMAT AUTOIMMUNE DIS NUTLEY NJ 07110 F HOFFMANN LA ROCHE INC BASEL SWITZERLAND
Titolo Testata:
Journal of immunotherapy with emphasis on tumor immunology
fascicolo: 2, volume: 17, anno: 1995,
pagine: 71 - 77
SICI:
1067-5582(1995)17:2<71:ROIIMT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL STIMULATORY FACTOR; IFN-GAMMA; EXPRESSION; CLONING; INDUCTION; ALPHA; LINES; CDNA;
Keywords:
INTERLEUKIN-12; INTERFERON-GAMMA; ANTITUMOR ACTIVITY; CYTOKINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Brunda et al., "ROLE OF INTERFERON-GAMMA IN MEDIATING THE ANTITUMOR EFFICACY OF INTERLEUKIN-12", Journal of immunotherapy with emphasis on tumor immunology, 17(2), 1995, pp. 71-77

Abstract

Although interleukin-12 (IL-12) has marked antitumor activity againstthe murine Renca renal cell carcinoma in vivo, no antiproliferative activity with IL-12 was observed against these tumor cells in vitro; incontrast, interferon-gamma (IFN-gamma) had growth inhibitory activity. Since one of the properties of IL-12 is its ability to stimulate production of IFN-gamma, the role of IFN-gamma in mediating the antitumoractivity of IL-12 was evaluated. Substantially diminished antitumor activity was observed in mice injected with IL-12 and neutralizing antibody to murine IFN-gamma compared with mice receiving IL-12 alone, indicating that IFN-gamma was required for the optimal antitumor efficacyof IL-12. However, several lines of investigation suggest that the antitumor effect of IL-12 is not mediated solely through the induction of IFN-gamma. Exogenous administration of IFN-gamma to Renca tumor-bearing euthymic mice resulted in less antitumor efficacy than that which could be obtained with IL-12. In addition, the antitumor effect of IL-12 was reduced in nude mice compared with euthymic mice, but an similar to 10-fold higher level of serum IFN-gamma was induced in nude than in euthymic mice. Thus, these results indicate that induction of high serum levels of IFN-gamma is not sufficient to mediate the antitumor efficacy of IL-12.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:36:17