Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HUMAN CHORIONIC-GONADOTROPIN IMMUNOACTIVITY IN CYSTIC INTRACRANIAL TUMORS
Autore:
HONEGGER J; MANN K; THIERAUF P; ZRINZO A; FAHLBUSCH R;
Indirizzi:
UNIV ERLANGEN NURNBERG,DEPT NEUROSURG,SCHWABACHANLAGE 6 D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,DEPT PATHOL D-91054 ERLANGEN GERMANY UNIV ESSEN GESAMTHSCH,DEPT CLIN ENDOCRINOL D-45122 ESSEN GERMANY
Titolo Testata:
Clinical endocrinology
fascicolo: 3, volume: 42, anno: 1995,
pagine: 235 - 241
SICI:
0300-0664(1995)42:3<235:HCIICI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERM-CELL TUMORS; FREE BETA-SUBUNIT; CRANIOPHARYNGIOMAS; PITUITARY; HCG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
J. Honegger et al., "HUMAN CHORIONIC-GONADOTROPIN IMMUNOACTIVITY IN CYSTIC INTRACRANIAL TUMORS", Clinical endocrinology, 42(3), 1995, pp. 235-241

Abstract

BACKGROUND AND OBJECTIVE With regard to intracranial tumours, elevated hCG in CSF or serum has been considered to be specific for germ-celltumours, Recently however, elevated hCG has also been shown to be present in cyst fluid and CSF of patients with craniopharyngiomas. While germ-cell tumours are generally non-cystic, the aim of our study was to determine the significance of hCG in cystic intracranial lesions. DESIGN In a prospective study, hCG immunoactivity and subunits of hCG were measured in cyst fluid, CSF, and serum of patients harbouring intracranial cyst lesions. PATIENTS AND MEASUREMENTS hCG immunoactivity wasmeasured in cyst fluid and serum samples of 42 patients, CSF samples were available from 12 patients with craniopharyngiomas. In order to fully characterize the hCG immunoactivity, we used immunoradiometric assays for total hCG activity (measuring both intact hCG and the free beta-subunit of hCG), and those specific for intact, dimeric hCG (hCG), free beta-subunit of hCG (hCG beta) and free alpha-subunit. Furthermore, immunostaining of tumour tissue was performed using monoclonal antibodies directed against the free beta-subunit of hCG. RESULTS Total hCG immunoactivity was markedly elevated in cyst fluid of all 17 craniopharyngiomas (range 36 7-4558 IU/I; normal < 5 IU/I). Moderately elevated levels of hCG in cyst fluid were detected in three of four pituitary adenomas, in two metastases from lung cancer and in two arachnoid cysts. hCG beta was detected In cyst fluid from all hCG positive cysts, while specific determination of intact (dimer) hCG and alpha-subunit mostly yielded negative results. No hCG immunoactivity was found in cystic gliomas, meningiomas or haemangloblastomas. hCG was elevated in CSF of two patients with craniopharyngiomas, but no hCG immunoactivity was detected in any serum sample. Subtle immunostaining of epithelial cell groups was shown in five of ten craniopharyngiomas. Clear immunostaining for hCG beta was also found in scattered epithelial cells of one pituitary adenoma. CONCLUSIONS hCG immunoactivity in cystic intracranial lesions is due mainly to hCG beta. Measurement of hCG immunoactivity in cyst fluid can be helpful in the differential diagnosis of intracranial cystic lesions, if surgery is restricted to cyst decompression and no histology is available. High levels suggest a craniopharyngioma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:00:18