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Titolo:
FLUID AND PROTEIN SECRETION FROM FERRET SUBMANDIBULAR AND PAROTID-GLANDS IN RESPONSE TO SYMPATHETIC-NERVE STIMULATION OR ADMINISTRATION OF SYMPATHOMIMETICS
Autore:
TOBIN G; MIRFENDERESKI S; AHSTROM T; EKSTROM J;
Indirizzi:
GOTHENBURG UNIV,DEPT PHYSIOL & PHARMACOL,DIV PHARMACOL,MEDICINAREGATAN 7 S-41390 GOTHENBURG SWEDEN
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 3, volume: 153, anno: 1995,
pagine: 231 - 241
SICI:
0001-6772(1995)153:3<231:FAPSFF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; SALIVARY-GLANDS; INNERVATION; AMYLASE; CATS;
Keywords:
ADRENOCEPTORS; FERRET; FLUID SECRETION; PROTEIN SECRETION; SALIVARY GLANDS; SYMPATHETIC INNERVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
G. Tobin et al., "FLUID AND PROTEIN SECRETION FROM FERRET SUBMANDIBULAR AND PAROTID-GLANDS IN RESPONSE TO SYMPATHETIC-NERVE STIMULATION OR ADMINISTRATION OF SYMPATHOMIMETICS", Acta Physiologica Scandinavica, 153(3), 1995, pp. 231-241

Abstract

Electrical stimulation of the sympathetic innervation evoked secretion of submandibular and parotid saliva. By changing the mode of stimulation from a continuous to an intermittent one the fluid response increased and glandular blood flow improved. The volumes from the submandibular glands were larger than those from the parotid glands and further, the protein concentration of submandibular saliva was higher than that of parotid saliva. Adrenaline, isoprenaline and phenylephrine evoked larger fluid responses from submandibular than from parotid glands. However, the fluid response was small compared to the parasympathetic one. Substance P-evoked saliva was used as carrier for protein released by sympathetic nerve stimulation or administration of adrenaline andisoprenaline. In vitro tissues of submandibular and parotid glands responded to adrenaline with a dose-dependent release of protein. Taken together, the analytical pharmacology performed in vivo and in vitro, and including the antagonists phentolamine, dihydroergotamine, propranolol and metoprolol, showed that in submandibular glands, alpha(alpha 1)adrenoceptors were predominantly involved in fluid secretion and beta(beta(1))-adrenoceptors predominantly involved in protein secretion. In parotid glands, fluid secretion seemed solely to depend on alpha(alpha 1)-adrenoceptors, while beta(beta 1)-adrenoceptors seemed almost solely involved in protein secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 10:58:11