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Titolo:
RETENTION AND MULTILINEAGE EXPRESSION OF HUMAN HEMATOPOIETIC STEM-CELLS IN HUMAN-SHEEP CHIMERAS
Autore:
ZANJANI ED; ALMEIDAPORADA G; FLAKE AW;
Indirizzi:
UNIV NEVADA,DEPT VET AFFAIRS MED CTR,SCH MED,DEPT MED,151B,1000 LOCUST ST RENO NV 89520 CHILDRENS HOSP MICHIGAN,DEPT SURG DETROIT MI 48201
Titolo Testata:
Stem cells
fascicolo: 2, volume: 13, anno: 1995,
pagine: 101 - 111
SICI:
1066-5099(1995)13:2<101:RAMEOH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW CELLS; SCID-HU MOUSE; PROGENITOR CELLS; COMPETITIVE REPOPULATION; MICE; TRANSPLANTATION; INUTERO; ENGRAFTMENT; INVITRO; DIFFERENTIATION;
Keywords:
HEMATOPOIETIC STEM CELLS; XENOGENEIC TRANSPLANTATION; IN UTERO TRANSPLANTATION; HUMAN, SHEEP XENOGRAFT; PREIMMUNE FETUS; FETAL LIVER; STEM CELL ASSAY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
E.D. Zanjani et al., "RETENTION AND MULTILINEAGE EXPRESSION OF HUMAN HEMATOPOIETIC STEM-CELLS IN HUMAN-SHEEP CHIMERAS", Stem cells, 13(2), 1995, pp. 101-111

Abstract

We have taken advantage of the permissive environment of the early gestational age fetus to engraft human hematopoietic stem cells (HSC) into preimmune fetal lambs, The resulting chimeras exhibit long-term multilineage engraftment of human cells in the bone marrow (BM) and peripheral blood (PB). Long-term multilineage reconstitution of second generation recipients by human cells isolated from chimeric sheep BM indicates that the engraftment in this model involved long-term repopulating human HSC. The model appears to be sensitive enough to detect relatively small numbers of transplanted HSC from pre- and postnatal human sources. Finally, transplantation of mature T lymphocyte-containing cells from a variety of sources results in lethal graft-versus-host disease (GVHD), analogous to clinical BM transplantation, suggesting that, at least in some respects, the model is biologically relevant, The human-sheep model is promising and may have important advantages over murine models for the in vivo study of normal and abnormal hematopoiesis and as a potential assay system for human HSC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:31:42