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Titolo:
SMOKING AND RISK OF ENDOMETRIAL CANCER - RESULTS FROM AN ITALIAN CASE-CONTROL STUDY
Autore:
PARAZZINI F; LAVECCHIA C; NEGRI E; MORONI S; CHATENOUD L;
Indirizzi:
IST RIC FARMACOL MARIO NEGRI MILAN ITALY UNIV MILAN,OSTETR GINECOL CLIN 1 MILAN ITALY UNIV MILAN,IST STAT MED & BIOMETRIA MILAN ITALY
Titolo Testata:
Gynecologic oncology
fascicolo: 2, volume: 56, anno: 1995,
pagine: 195 - 199
SICI:
0090-8258(1995)56:2<195:SAROEC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIGARETTE-SMOKING; REPLACEMENT THERAPY; EPIDEMIOLOGY; MENOPAUSE; WOMEN; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
F. Parazzini et al., "SMOKING AND RISK OF ENDOMETRIAL CANCER - RESULTS FROM AN ITALIAN CASE-CONTROL STUDY", Gynecologic oncology, 56(2), 1995, pp. 195-199

Abstract

To determine the relationship between cigarette smoking and endometrial cancer, we conducted a case-control study. The cases were 726 patients with histologically confirmed endometrial cancers 74 years of age or less (median age, 59 years; range, 31-74) admitted between 1983 and1992 to the Ospedale Maggiore (including the four largest teaching and general hospitals in the greater Milan area), to the Obstetrics and Gynecology University Clinics, and to the National Cancer Institute ofMilan. The controls were 1452 patients younger than 75 years (median age, 59; range, 25-74) admitted for acute, nongynecological, nonhormonal, nonneoplastic conditions to the same network of hospitals where cases had been identified. Cases were less frequently ever-smokers (19%)than controls (25%). In comparison with never-smokers, the relative risk (RR) of endometrial cancer was 0.8 (95% confidence interval, CI, 0.7-1.1) in current smokers and 0.6 (95% CI 0.4-0.9) in ex-smokers. Therisk of endometrial cancer decreased with number of cigarettes smokedper day and duration of habit. The estimated RR were, in comparison with never-smokers, 0.8 and 0.6 respectively in smokers of less than 20and 20 or more cigarettes per day (chi(1)(2) trend 5.48, P = 0.02) and 1.0 and 0.5 in ever-smokers for less than 20 and for 20 years or more. There was no clear relation with time since first smoking, but the RR was lower in ex-smokers who had stopped smoking less than 10 years before the interview (RR, 0.4; 95% CI, 0.2-0.8) than in those who had stopped 10 years or more before (RR, 0.8; 95% CI, 0.5-1.4). The estimated RR for ever-smokers was close to unity in premenopausal women, butapparently stronger in premenopause. Likewise the RR was 0.9 in lean (<25 Quetelet's index) smoking women in comparison with lean nonsmokers, but smoking appeared to reduce the association with overweight. Theestimated RR of endometrial cancer, in comparison with nonsmokers with Quetelet's index <25 was 2.0 in nonsmokers with Quetelet's index greater than or equal to 25, and 1.3 in smokers with Quetelet's index greater than or equal to 25. These findings confirm the role of smoking on endometrial cancer risk. This risk reduction is, however, moderate in relative terms, and negligible from a public health point of view, in consideration of the negative consequences of smoking in several other diseases. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:43:56