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Titolo:
IDENTIFICATION OF CIRCADIAN GENE-EXPRESSION IN THE RAT PINEAL-GLAND AND RETINA BY MESSENGER-RNA DIFFERENTIAL DISPLAY
Autore:
GAUER F; KEDZIERSKI W; CRAFT CM;
Indirizzi:
UNIV SO CALIF,SCH MED,DEPT CELL & NEUROBIOL,BMT 401,1333 SAN PABLO STLOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT CELL & NEUROBIOL LOS ANGELES CA 90033 DOHENY EYE INST,MARY D ALLEN LABS LOS ANGELES CA 90033 UNIV TEXAS,SW MED SCH,DEPT PSYCHIAT DALLAS TX 00000
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 187, anno: 1995,
pagine: 69 - 73
SICI:
0304-3940(1995)187:1<69:IOCGIT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROMOTES NEURITE OUTGROWTH; MESSENGER-RNA; MELATONIN; REPRODUCTION; ADHESION; CLONING; SIGNAL;
Keywords:
PINEAL GLAND; RETINA; MESSENGER-RNA DIFFERENTIAL DISPLAY; PROTEIN F3; CIRCADIAN RHYTHM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
F. Gauer et al., "IDENTIFICATION OF CIRCADIAN GENE-EXPRESSION IN THE RAT PINEAL-GLAND AND RETINA BY MESSENGER-RNA DIFFERENTIAL DISPLAY", Neuroscience letters, 187(1), 1995, pp. 69-73

Abstract

To identify unique gene products that could be crucial for circadian and light-dark regulations, using the technology of differential display, we have investigated mRNAs that were isolated from rat pineals andretinas collected either during subjective day (D) or subjective night (N). A subpopulation of about 50 mRNAs were amplified from pineal using designed primers and reverse transcriptase-polymerase chain reaction. Thirty five of the mRNAs were expressed equivalently in both D andN samples. From the 15 mRNAs showing differential expression, four amplified products were selected, based on higher expression during the subjective night (N310, N320, N383, N420) and each was subcloned and sequenced. Of the four cDNAs studied, only N310 was determined to have significant identity to a known cell adhesion protein, called F3. Thisprotein is highly expressed in developing mouse neurons and is related to chicken contactin. Each differentially displayed product identified is being examined further in order to understand their potential significance in the circadian regulation of pineal and retinal activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 00:00:32