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Titolo:
INTERLEUKIN-2 INDUCES AN EARLY STEP IN THE ACTIVATION OF INTERFERON-GAMMA GENE-EXPRESSION
Autore:
ARAD G; NUSSINOVICH R; KAEMPFER R;
Indirizzi:
HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MOLEC VIROL IL-91120 JERUSALEM ISRAEL
Titolo Testata:
Immunology letters
fascicolo: 2-3, volume: 44, anno: 1995,
pagine: 213 - 216
SICI:
0165-2478(1995)44:2-3<213:IIAESI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; IL-2 RECEPTOR; STIMULATORY FACTOR; SIGNALS; RESPONDER; CHAIN; NK;
Keywords:
INTERLEUKIN-2; COSTIMULATORY FACTOR; HUMAN INTERFERON-GAMMA GENE EXPRESSION; MITOGENIC INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
G. Arad et al., "INTERLEUKIN-2 INDUCES AN EARLY STEP IN THE ACTIVATION OF INTERFERON-GAMMA GENE-EXPRESSION", Immunology letters, 44(2-3), 1995, pp. 213-216

Abstract

Establishment of protective immunity depends critically on IFN-gamma. We show that in human peripheral blood mononuclear cells, low doses of IL-2 greatly potentiate the response of the IFN-gamma gene to mitogen, by over 100-fold. By itself, IL-2 is unable to induce IFN-gamma mRNA to a significant extent. Yet, exposure to IL-2 leads to cellular commitment within a few hours, expressed by greatly enhanced accumulationof IFN-gamma mRNA upon subsequent exposure to phytohemagglutinin. Changes induced by IL-2 do not relieve the requirement for de novo protein synthesis during the early phases of induction of IFN-gamma gene expression. IL-2 may induce a component essential for induction of IFN-gamma mRNA that is utilized during subsequent exposure to a mitogenic signal. Our results demonstrate synergy between IL-2 and mitogen in IFN-gamma gene induction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 02:31:19