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Titolo:
ROLE OF PROTEIN ADSORPTION ON HEMODIALYSIS-INDUCED COMPLEMENT ACTIVATION AND NEUTROPHIL DEFECTS
Autore:
NEVECERAL P; MARKERT M; WAUTERS JP;
Indirizzi:
CHU VAUDOIS,DIV NEPHROL CH-1011 LAUSANNE SWITZERLAND UNIV LAUSANNE HOSP,DIV NEPHROL LAUSANNE SWITZERLAND UNIV LAUSANNE HOSP,CLIN CHEM LAB LAUSANNE SWITZERLAND
Titolo Testata:
Nephrology, dialysis, transplantation
fascicolo: 3, volume: 10, anno: 1995,
pagine: 372 - 376
SICI:
0931-0509(1995)10:3<372:ROPAOH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMODIALYSIS MEMBRANES; MECHANISMS;
Keywords:
BIOCOMPATIBILITY; COMPLEMENT; LEUKOPENIA; HEMODIALYSIS; NEUTROPHIL FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
P. Neveceral et al., "ROLE OF PROTEIN ADSORPTION ON HEMODIALYSIS-INDUCED COMPLEMENT ACTIVATION AND NEUTROPHIL DEFECTS", Nephrology, dialysis, transplantation, 10(3), 1995, pp. 372-376

Abstract

The present clinical study investigated the role of protein adsorption on complement activation and neutrophil functions during in vivo haemodialysis. The parameters were measured simultaneously at the arterial and venous sites of a cuprophan (CU) dialyser with or without pretreatment with human albumin, human immunoglobulins or human total plasmaproteins (PLP). Leukocyte count, complement activation (C3a des arg),oxygen radical production and chemotaxis were measured at time zero and 15 min at the arterial and venous sites of the dialyser. Leukopeniaobserved at both sites was prevented only with PLP treatment. Complement activation was maximal at the venous site, but was not prevented by any of the treatments. Neutrophil oxygen radical production and chemotaxis were significantly decreased only at the venous site and restored to normal with any of the three treatments. Complement activation was maximal at the venous site, but was not prevented by any of the treatments. Protein adsorption on the dialyser membrane seems to modulatethe bioincompatibility parameters in a different way. Depending on the functions tested, the protein fractions have different protecting effects, indicating the multifactorial mechanism implicated in the CU haemodialysis-induced leukopenia, complement activation and neutrophil defect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 11:03:47