Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
POTENTIATING EFFECTS OF BETA-EUDESMOL-RELATED CYCLOHEXYLIDENE DERIVATIVES ON SUCCINYLCHOLINE-INDUCED NEUROMUSCULAR BLOCK IN ISOLATED PHRENIC NERVE-DIAPHRAGM MUSCLES OF NORMAL AND ALLOXAN-DIABETIC MICE
Autore:
KIMURA M; DIWAN PV; YANAGI S; KONNO Y; NOJIMA H; KIMURA I;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,2630 SUGITANI TOYAMA 93001 JAPAN TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL TOYAMA 93001 JAPAN INDIAN INST CHEM TECHNOL,DIV PHARMACOL HYDERABAD 500007 ANDHRA PRADESH INDIA TAIHO PHARMACEUT,HANNO RES CTR,CHEM LAB HANNO SAITAMA 357 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 3, volume: 18, anno: 1995,
pagine: 407 - 410
SICI:
0918-6158(1995)18:3<407:PEOBCD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHANNEL; DESENSITIZATION;
Keywords:
BETA-EUDESMOL-RELATED COMPOUND; CYCLOHEXYLIDENE DERIVATIVE; NEUROMUSCULAR BLOCKADE; SUCCINYLCHOLINE; POTENTIATION; DIABETIC MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
M. Kimura et al., "POTENTIATING EFFECTS OF BETA-EUDESMOL-RELATED CYCLOHEXYLIDENE DERIVATIVES ON SUCCINYLCHOLINE-INDUCED NEUROMUSCULAR BLOCK IN ISOLATED PHRENIC NERVE-DIAPHRAGM MUSCLES OF NORMAL AND ALLOXAN-DIABETIC MICE", Biological & pharmaceutical bulletin, 18(3), 1995, pp. 407-410

Abstract

beta-Eudesmol, a sesquiterpenoid alcohol contained in Atractylodes lancea, potentiates succinylcholine (SuCh)-induced neuromuscular blockade. The potentiating effect is greater in diabetic muscles than in normal ones. As a ligand for affinity chromatography to study the potentiating mechanism, me designed and synthesized newly beta-eudesmol-related cyclohexylidene derivatives (2-(3-hydroxy-3-methylbutyl)cyclohexylidene; KTE-13, 2-(3-hydroxy-3-methylbutyl)-4-cyclohexylidene carboxylic acid; KTE-32 and 4-tert-butoxycarbonyl-2-(3-hydroxy-3-methylbutyl) cyclohexylidene; KTE-33). We examined the potentiating effects of those compounds in phrenic nerve-diaphragm muscle preparations of normal and alloxan-diabetic mice. KTE-33 (100 mu M) potentiated more greatly SuCh-induced neuromuscular blockade in diabetic muscles than in normal ones (the potentiating ratios in normal and diabetic muscles were 6.7 and10.6, respectively), while MTE-13 (100 mu M) and -32 (200 mu M) potentiated weakly. These results suggest that the ester group in KTE-33 rather than a carboxyl group in KTE-32 is important in inducing the potentiation of SuCh-induced neuromuscular blockade in diabetic state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:19:46