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Titolo:
INFLAMMATORY PROCESSES INDUCE BETA-AMYLOID PRECURSOR PROTEIN-CHANGES IN MOUSE-BRAIN
Autore:
BRUGG B; DUBREUIL YL; HUBER G; WOLLMAN EE; DELHAYEBOUCHAUD N; MARIANI J;
Indirizzi:
UNIV PARIS 06,INST NEUROSCI,DEV NEUROBIOL LAB,CNRS,URA 1488 F-75005 PARIS FRANCE UNIV PARIS 06,INST NEUROSCI,DEV NEUROBIOL LAB,CNRS,URA 1488 F-75005 PARIS FRANCE HOP COCHIN,INSERM,U283 F-75014 PARIS FRANCE F HOFFMANN LA ROCHE CH-4000 BASEL SWITZERLAND
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 7, volume: 92, anno: 1995,
pagine: 3032 - 3035
SICI:
0027-8424(1995)92:7<3032:IPIBPP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE PHASE RESPONSE; ALZHEIMERS-DISEASE; MESSENGER-RNA; TRANSGENIC MICE; STAGGERER MOUSE; MUTANT MICE; RAT-BRAIN; INTERLEUKIN-1; CELLS; MACROPHAGES;
Keywords:
NEURODEGENERATION; CEREBELLUM; STAGGERER MICE; INTERLEUKIN 1; INTERLEUKIN 6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
B. Brugg et al., "INFLAMMATORY PROCESSES INDUCE BETA-AMYLOID PRECURSOR PROTEIN-CHANGES IN MOUSE-BRAIN", Proceedings of the National Academy of Sciences of the United Statesof America, 92(7), 1995, pp. 3032-3035

Abstract

In Alzheimer disease, a combination of genetic predisposition and environmental factors may contribute to changes in beta-amyloid precursorprotein (APP) expression, beta-amyloid peptide deposition, and neuronal loss. Factors such as head injury or acute infection that trigger inflammatory processes may play a crucial role in development of the disease. In the present in vivo study, we showed that, in mouse brain, peripheral stimulation with lipopolysaccharide (LPS) induced a transient increase in the inflammatory cytokine mRNAs (interleukin 1 beta and interleukin 6), followed by changes in expression of APP isoforms in the cerebellum but not in the cerebral cortex. These changes consisted of a decrease in the APP-695 and an increase in the Kunitz protease inhibitor-bearing isoforms (KPI-APP). In the cerebellum of the staggerermouse mutant, where a severe loss of Purkinje and granule cells occurs, basal mRNA levels of these interleukins were elevated and an increase in the KPI-APP/APP-695 ratio compared to wild-type mice was observed. These abnormalities were further accentuated by LPS stimulation. This study shows that acute and chronic inflammatory processes play an important role in changes in APP expression possibly associated with neurodegeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:07:21