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Titolo:
EXPRESSION OF AN AMPHIBIAN HOMOLOG OF THE EPH FAMILY OF RECEPTOR TYROSINE KINASES IS DEVELOPMENTALLY-REGULATED
Autore:
JONES TL; KARAVANOVA I; MAENO M; ONG RC; KUNG HF; DAAR IO;
Indirizzi:
NCI,FREDERICK CANC RES & DEV CTR,LEUKOCYTE BIOL LAB,BIOL RESPONSE MODIFIERS PROGRAM FREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,LEUKOCYTE BIOL LAB,BIOL RESPONSE MODIFIERS PROGRAM FREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB FREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,BIOCHEM PHYSIOL LAB FREDERICK MD 21702
Titolo Testata:
Oncogene
fascicolo: 6, volume: 10, anno: 1995,
pagine: 1111 - 1117
SICI:
0950-9232(1995)10:6<1111:EOAAHO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
XENOPUS-EMBRYOS; PROTEIN-KINASES; CDNA CLONING; W-LOCUS; GENE; MOUSE; DROSOPHILA; IDENTIFICATION; ENCODES; CHICKEN;
Keywords:
EPH; TYROSINE KINASE; XENOPUS LAEVIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Jones et al., "EXPRESSION OF AN AMPHIBIAN HOMOLOG OF THE EPH FAMILY OF RECEPTOR TYROSINE KINASES IS DEVELOPMENTALLY-REGULATED", Oncogene, 10(6), 1995, pp. 1111-1117

Abstract

In order to study the function of tyrosine kinase receptors during Xenopus development, we have isolated Xek (Xenopus Elk-like kinase), a tyrosine kinase receptor, which shows significant homology to rat Elk and chicken cek5, members of the Eph family. Xek exists as a maternallyexpressed mRNA which decreases in expression at the mid blastula transition and reappears at late neurulation in Xenopus, Xek mRNA is expressed at higher levels in the anterior and dorsal regions of embryonic stages 16, 24 and 37. In adult Xenopus tissues, Xek appears to be ubiquitously expressed with higher expression observed in brain and ovary,In situ hybridization analysis demonstrates localized mRNA expressionin the brain, brachial arches, trigeminal facial ganglion, and the retina of the swimming tadpole stage of development. The similarities insequence and expression pattern suggest that Xek is an amphibian member of the Eph family and may play a role in the development or function of the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:15:31