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Titolo:
ANTIVIRAL ACTIVITY OF AN IMMUNOMODULATORY LIPOPHILIC DESMURAMYL DIPEPTIDE ANALOG
Autore:
SIDWELL RW; SMEE DF; HUFFMAN JH; BAILEY KW; WARREN RP; BURGER RA; PENNEY CL;
Indirizzi:
UTAH STATE UNIV,INST ANTIVIRAL RES LOGAN UT 84322 BIOCHEM THERAPEUT INC LAVAL PQ CANADA
Titolo Testata:
Antiviral research
fascicolo: 2, volume: 26, anno: 1995,
pagine: 145 - 159
SICI:
0166-3542(1995)26:2<145:AAOAIL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE CYTOMEGALOVIRUS-INFECTION; BIOLOGICAL RESPONSE MODIFIERS; INFLUENZA-VIRUS INFECTION; MEDIATED RESISTANCE; NK CELLS; MICE; INTERFERON; INDUCTION; COMPLEX; INVIVO;
Keywords:
BCH-527; MURINE CYTOMEGALOVIRUS (MCMV); INFLUENZA A (H1N1) VIRUS; PUNTA TORO VIRUS (PTV);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Sidwell et al., "ANTIVIRAL ACTIVITY OF AN IMMUNOMODULATORY LIPOPHILIC DESMURAMYL DIPEPTIDE ANALOG", Antiviral research, 26(2), 1995, pp. 145-159

Abstract

BCH-527, the lipophilic hydrochloride salt of octadecyl D-alanyl L-glutamine, was evaluated for efficacy against experimentally induced murine cytomegalovirus (MCMV), influenza A (H1N1) (IV-A), and Punta Toro virus (PTV) infections in mice. The compound was administered i.p. every other day for a total of 4 injections commencing 24 h previrus exposure. Doses ranged from 12.5 to 200 mg/kg per injection in the variousexperiments. The MCMV infection was significantly inhibited in two experiments by doses of 25-200 mg/kg, as manifested by increased numbersof survivors and decreased titers of virus recoverable from tissues. The IV-A infection was weakly inhibited, with antiviral activity seen in lowered lung scores and lung weights and less decline in arterial oxygen saturation values. The PTV infection was not inhibited. BCH-527 was stimulatory to cytotoxic T-cells, natural killer (NK) cells, macrophages, and splenic B-cells. The highest dose tested, 200 mg/kg, was inhibitory to cytotoxic T-cell activity and to some extent to NK cell and macrophage activity. These data suggest BCH-527 functions as an immune modulator in exerting the observed antiviral activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:35:49