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Titolo:
MEMORY B-CELLS FROM HUMAN TONSILS COLONIZE MUCOSAL EPITHELIUM AND DIRECTLY PRESENT ANTIGEN TO T-CELLS BY RAPID UP-REGULATION OF B7-1 AND B7-2
Autore:
LIU YJ; BARTHELEMY C; DEBOUTEILLER O; ARPIN C; DURAND I; BANCHEREAU J;
Indirizzi:
SCHERING PLOUGH CORP,IMMUNOL RES LAB,27 CHEM PEUPLIERS,BP 11 F-69571 DARDILLY FRANCE
Titolo Testata:
Immunity
fascicolo: 3, volume: 2, anno: 1995,
pagine: 239 - 248
SICI:
1074-7613(1995)2:3<239:MBFHTC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERMINAL-CENTERS; COSTIMULATORY ACTIVITY; PROTEIN ANTIGENS; ANTIBODY MUTANTS; DRIVEN SELECTION; ACTIVATION; INDUCTION; LIGAND; LYMPHOCYTES; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
Y.J. Liu et al., "MEMORY B-CELLS FROM HUMAN TONSILS COLONIZE MUCOSAL EPITHELIUM AND DIRECTLY PRESENT ANTIGEN TO T-CELLS BY RAPID UP-REGULATION OF B7-1 AND B7-2", Immunity, 2(3), 1995, pp. 239-248

Abstract

Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD(+) naive a cells and CD38() germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils. Memory a cells but not naive B cells have the capacity to present antigen directly to T cells, owing to the constitutive expression of the accessory molecules B7-1/CD80 and B7-2/CD86. Signals through antigen receptors and CD40 antigen result in these two molecules being further up-regulated more rapidly and strongly on memory a cells than on naive B cells. The unique anatomical localization of memory B cells beneath the surface of mucosa, together with their strong APC capacity, may explain the well-known prompt and robust secondary antibody responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:18:05