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Titolo:
DOUBLE-BLIND PLACEBO-CONTROLLED MULTICENTER STUDY OF GINKGOLIDE-B IN TREATMENT OF ACUTE EXACERBATIONS OF MULTIPLE-SCLEROSIS
Autore:
BROCHET B; GUINOT P; ORGOGOZO JM; CONFAVREUX C; RUMBACH L; LAVERGNE V; BOULLIAT J; CAUSSANEL JP; CESARO P; CHEDRU F; COLLARD M; DEGOS CF; DESTEE A; GOAS JY; GONSETTE R; FEVE JR; ROULLET E; SETIEY A; VIALLET F; WARTER JM;
Indirizzi:
UNIV BORDEAUX 2,CTR HOSP,HOP PELLEGRIN,DEPT NEUROL F-33076 BORDEAUX FRANCE INST HENRI BEAUFOUR F-75116 PARIS FRANCE HOP ANTIQUAILLE,DEPT NEUROL F-69321 LYON FRANCE HOP JEAN MINJOZ,DEPT NEUROL F-25030 BESANCON FRANCE HOP CIVIL,DEPT NEUROL STRASBOURG FRANCE CHR AIX EN PROVENCE,DEPT NEUROL AIX EN PROVENCE FRANCE CTR HOSP VILLEFRANCHE SUR SAONE,DEPT NEUROL VILLEFRANCHE SUR SAONE FRANCE HOP TENON,DEPT NEUROL PARIS FRANCE HOP LAENNEC,DEPT NEUROL NANTES FRANCE MS NATL CTR MELSBROEK BELGIUM CTR HOSP BREST,DEPT NEUROL BREST FRANCE HOP LILLE,DEPT NEUROL LILLE FRANCE HOP ST JOSEPH,DEPT NEUROL PARIS FRANCE HOP CIVIL,DEPT NEUROL STRASBOURG FRANCE CTR HOSP MEAUX,DEPT NEUROL MEAUX FRANCE HOP HENRI MONDOR,DEPT NEUROL CRETEIL FRANCE CTR HOSP AUCH,DEPT NEUROL AUCH FRANCE CTR HOSP BOURG EN BRESSE,DEPT NEUROL BOURG EN BRESSE FRANCE
Titolo Testata:
Journal of Neurology, Neurosurgery and Psychiatry
fascicolo: 3, volume: 58, anno: 1995,
pagine: 360 - 362
SICI:
0022-3050(1995)58:3<360:DPMSOG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE OPTIC NEURITIS; INTRAVENOUS METHYLPREDNISOLONE; CONTROLLED TRIAL; CORTICOSTEROIDS;
Keywords:
MULTIPLE SCLEROSIS; GINKGOLIDE B;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
B. Brochet et al., "DOUBLE-BLIND PLACEBO-CONTROLLED MULTICENTER STUDY OF GINKGOLIDE-B IN TREATMENT OF ACUTE EXACERBATIONS OF MULTIPLE-SCLEROSIS", Journal of Neurology, Neurosurgery and Psychiatry, 58(3), 1995, pp. 360-362

Abstract

After an open labelled pilot study of ginkgolide B, a potent inhibitor of platelet activating factor, in the treatment of acute exacerbations of multiple sclerosis, a randomised double blind placebo controlledstudy was undertaken. One hundred and four patients were enrolled in the study: for seven days 43 received placebo, 29 received 240 mg/day ginkgolide B and 32 received 360 mg/day ginkgolide B. There was no statistical difference between the three groups for changes in Rankin, Kurtzke expanded disability status scale (EDSS), and Hauser ambulation index (AI) scores. Although there was a trend in favour of groups treated with ginkgolide for a change of Rankin and AI scores, it is concluded that ginkgolide B is not an effective treatment of exacerbations ofmultiple sclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:20:49