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Titolo:
ALCOHOL-DRINKING IN RATS INJECTED ICV WITH 6-OHDA - EFFECT OF 8-OHDPAT AND TROPISETRON (ICS-205930)
Autore:
JANKOWSKA E; BIDZINSKI A; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT BIOCHEM PL-02957 WARSAW POLAND
Titolo Testata:
Alcohol
fascicolo: 2, volume: 12, anno: 1995,
pagine: 121 - 126
SICI:
0741-8329(1995)12:2<121:AIRIIW>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; FREELY MOVING RATS; ETHANOL-CONSUMPTION; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; PREFERRING P; 5-HT3 RECEPTORS; UPTAKE BLOCKADE; BRAIN; ANTAGONIST;
Keywords:
ETHANOL; 6-HYDROXYDOPAMINE; ETHANOL PREFERENCE; 8-OHDPAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
E. Jankowska et al., "ALCOHOL-DRINKING IN RATS INJECTED ICV WITH 6-OHDA - EFFECT OF 8-OHDPAT AND TROPISETRON (ICS-205930)", Alcohol, 12(2), 1995, pp. 121-126

Abstract

6-Hydroxydopamine (6-OHDA) was administered ICV to Wistar male rats. Lesioned animals displayed lower preference for ethanol (ETOH) than sham-operated rats. Among 6-OHDA lesioned rats only 9% became high-preferring whereas 20% of sham-operated animals became high-preferring ones. Both tropisetron (the antagonist of 5-HT3 receptors) and 8-OHDPAT (the 5-HT1A receptor agonist) reduced ETOH drinking in high-preferring rats. However, in 6-OHDA lesioned rats the effect of tropisetron was reduced although 8-OHDA retained its effect on ETOH consumption. These results suggest that brain DA neurons are involved in tropisetron action but are not responsible for antipreference effect of 8-OHDPAT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:07:06