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Titolo:
SELECTION OF SPIROMETRIC MEASUREMENTS IN A CLINICAL-TRIAL, THE LUNG HEALTH STUDY
Autore:
WISE RA; CONNETT J; KURNOW K; GRILL J; JOHNSON L; KANNER R; ENRIGHT P;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT MED,5501 HOPKINS BAYVIEW CIRCLE BALTIMORE MD 21224 UNIV MINNESOTA,SCH PUBL HLTH,DEPT BIOSTAT MINNEAPOLIS MN 55455 UNIV UTAH,SCH MED,DEPT MED SALT LAKE CITY UT 00000 OREGON HLTH SCI UNIV,DEPT PHYSIOL PORTLAND OR 97201 UNIV ARIZONA,SCH MED,DEPT MED TUCSON AZ 00000
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 3, volume: 151, anno: 1995,
pagine: 675 - 681
SICI:
1073-449X(1995)151:3<675:SOSMIA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY-CONTROL; RELIABILITY; COEFFICIENT; FEV1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Wise et al., "SELECTION OF SPIROMETRIC MEASUREMENTS IN A CLINICAL-TRIAL, THE LUNG HEALTH STUDY", American journal of respiratory and critical care medicine, 151(3), 1995, pp. 675-681

Abstract

Although current recommendations for spirometry require that the largest value of FEV(1) and FVC should be taken from the largest values ofdifferent maneuvers, the validity of this approach was recently questioned. It has been suggested that selection of the maneuver with the largest peak flow or the maneuver with the largest FVC should be used for measurement of spirometric indices. The present analysis was therefore undertaken to determine which method of selection of spirometric maneuvers would give the least short-term variability in a clinical trial population. We examined the spirometry test sessions from 5,885 individuals with mild to moderate chronic airflow obstruction who were screened at two visits 24.9 +/- 17.1 d apart for entry into a multi-center clinical trial, the Lung Health Study. We compared eight potential selection methods for FEV(1) and FVC. Using these different selection methods, the coefficient of variation ranged from 4.1 to 4.9% for FEV(1) and from 3.5 to 5.7% for FVC. The average absolute difference between the two test sessions ranged from 110 to 123 ml for FEV(1) and from149 to 200 mi for FVC. Although all of the methods gave good results,the mean of the three highest values and the largest single value from all maneuvers provided the least short-term variability for both FEV(1) and FVC. We therefore conclude that there is no reason to change the currently recommended selection methods for FEV(1) and FVC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:47:25