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Titolo:
THE GAMMA-SUBUNIT OF THE ACETYLCHOLINE-RECEPTOR IS NOT EXPRESSED IN THE LEVATOR PALPEBRAE SUPERIORIS
Autore:
KAMINSKI HJ; KUSNER LL; NASH KV; RUFF RL;
Indirizzi:
CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,SCH MED,DEPT NEUROL,2074 ABINGTON RD CLEVELAND OH 44106 CLEVELAND VET AFFAIRS MED CTR CLEVELAND OH 00000
Titolo Testata:
Neurology
fascicolo: 3, volume: 45, anno: 1995,
parte:, 1
pagine: 516 - 518
SICI:
0028-3878(1995)45:3<516:TGOTAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYASTHENIA-GRAVIS; SKELETAL-MUSCLE; CALF-MUSCLE; CHANNELS; CDNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Kaminski et al., "THE GAMMA-SUBUNIT OF THE ACETYLCHOLINE-RECEPTOR IS NOT EXPRESSED IN THE LEVATOR PALPEBRAE SUPERIORIS", Neurology, 45(3), 1995, pp. 516-518

Abstract

In extraocular muscle (EOM), expression of the gamma-subunit, which is associated with the fetal-type acetylcholine receptor (AChR), may offer a differential target for immune-mediated damage and could explainthe preponderance of ocular manifestations caused by myasthenia gravis (MG). Using Poly(A)(+) RNA hybridization, we investigated expressionof the gamma-subunit in bovine levator palpebrae superioris (LP), a muscle also differentially involved by MG. There were no transcripts ofthe gamma-subunit of the AChR, but the epsilon-subunit, associated with the adult-type AChR, tvas present. The results indicate that the susceptibility of LP to MG is not mediated by gamma-subunit expression and suggest that multiterminal fibers in EOM may be the site of gamma-subunit expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:40:07